Integrating computational and biological hemodynamic approaches to improve modeling of atherosclerotic arteries

TNAM Vuong, M Bartolf‐Kopp, K Andelovic… - Advanced …, 2024 - Wiley Online Library
Atherosclerosis is the primary cause of cardiovascular disease, resulting in mortality,
elevated healthcare costs, diminished productivity, and reduced quality of life for individuals …

Mathematical modelling and simulation of atherosclerosis formation and progress: a review

NA Avgerinos, P Neofytou - Annals of Biomedical Engineering, 2019 - Springer
Cardiovascular disease (CVD) is a major threat to human health since it is the leading cause
of death in western countries. Atherosclerosis is a type of CVD related to hypertension …

Effects of different non-Newtonian models on unsteady blood flow hemodynamics in patient-specific arterial models with in-vivo validation

M Abbasian, M Shams, Z Valizadeh, A Moshfegh… - Computer methods and …, 2020 - Elsevier
The aim of this study is to demonstrate the implications of using different blood rheological
models in the simulation of blood flow dynamics in atherosclerotic coronary arteries …

Modeling of the early stage of atherosclerosis with emphasis on the regulation of the endothelial permeability

T Silva, W Jäger, M Neuss-Radu, A Sequeira - Journal of Theoretical …, 2020 - Elsevier
In this paper, we develop a mathematical model for the early stage of atherosclerosis, as a
chronic inflammatory disease. It includes also processes that are relevant for the” thickening” …

Simulation of atherosclerotic plaque growth using computational biomechanics and patient-specific data

DS Pleouras, AI Sakellarios, P Tsompou, V Kigka… - Scientific Reports, 2020 - nature.com
Atherosclerosis is the one of the major causes of mortality worldwide, urging the need for
prevention strategies. In this work, a novel computational model is developed, which is used …

An analytical method informed by clinical imaging data for estimating outlet boundary conditions in computational fluid dynamics analysis of carotid artery blood flow

M Kizhisseri, S Gharaie, J Schluter - Scientific Reports, 2023 - nature.com
Stroke occur mainly due to arterial thrombosis and rupture of cerebral blood vessels.
Previous studies showed that blood flow-induced wall shear stress is an essential bio …

Differential sensitivities to blood pressure variations in internal carotid and intracranial arteries: a numerical approach to stroke prediction

M Kizhisseri, S Gharaie, SR Boopathy, RP Lim… - Scientific Reports, 2023 - nature.com
Stroke remains a global health concern, necessitating early prediction for effective
management. Atherosclerosis-induced internal carotid and intra cranial stenosis contributes …

Effect of Reynolds number and blood viscosity models on the left coronary artery with multiple stenoses

R Pandey, PK Yadav - Physics of Fluids, 2022 - pubs.aip.org
This study aims to identify the significance of different blood viscosity models along with
different Reynolds numbers in the simulation of blood flow in a multi-stenosed Left Coronary …

Prediction of atherosclerotic disease progression using LDL transport modelling: a serial computed tomographic coronary angiographic study

A Sakellarios, CV Bourantas… - European Heart …, 2017 - academic.oup.com
Aim To investigate the efficacy of low-density lipoprotein (LDL) transport simulation in
reconstructed arteries derived from computed tomography coronary angiography (CTCA) to …

Relationship of endothelial shear stress with plaque features with coronary CT angiography and vasodilating capability with PET

GE Kalykakis, AS Antonopoulos, T Pitsargiotis… - Radiology, 2021 - pubs.rsna.org
Background Advances in three-dimensional reconstruction techniques and computational
fluid dynamics of coronary CT angiography (CCTA) data sets make feasible evaluation of …