Duchenne muscular dystrophy (DMD) is a monogenic muscle-wasting disorder and a
priority candidate for molecular and cellular therapeutics. Although rare, it is the most …

Extracellular matrix (ECM) is a kind of connective tissue in the cell microenvironment, which
is of great significance to tissue development. ECM in muscle fiber niche consists of three …

We present a DNA library preparation method that has allowed us to reconstruct a high-
coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The …

The dystrophin-glycoprotein complex was tested for interaction with several components of
the extracellular matrix as well as actin. The 156-kD dystrophin-associated glycoprotein (156 …

The X-linked muscle-wasting disease Duchenne muscular dystrophy is caused by mutations
in the gene encoding dystrophin. There is currently no effective treatment for the disease; …

Dystrophin is a long rod-shaped protein that connects the subsarcolemmal cytoskeleton to a
complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further …

Nitric oxide (NO) is synthesized in skeletal muscle by neuronal-type NO synthase (nNOS),
which is localized to sarcolemma of fast-twitch fibers. Synthesis of NO in active muscle …

The absence of dystrophin at the muscle membrane leads to Duchenne muscular dystrophy
(DMD), a severe muscle-wasting disease that is inevitably fatal in early adulthood. In …

Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

Dystrophin is a cytoskeletal protein of muscle fibers; its loss in humans leads to Duchenne
muscular dystrophy, an inevitably fatal wasting of skeletal and cardiac muscle. mdx mice …