Loss of cell cycle control is characteristic of tumorigenesis. The protein p21 is the founding
member of cyclin-dependent kinase inhibitors and an important versatile cell cycle protein …

Proliferating cell nuclear antigen (PCNA) plays an essential role in nucleic acid metabolism
as a component of the replication and repair machinery. This toroidal-shaped protein …

The development and progression of cancer1–3 and the experimental reversal of
tumorigenicity4, 5 are accompanied by complex changes in patterns of gene expression …

It has been proposed that the functions of the cyclin-dependent kinase inhibitors
p21Cip1/Waf1 and p27Kip1 are limited to cell cycle control at the G1/S-phase transition and …

Since its discovery, it has become increasingly clear that p21 can function as both a
classical tumour suppressor and an oncogene. In order to effectively utilize p21 as a …

Development of characteristic tissue patterns requires that individual cells be switched
locally between different phenotypes or “fates;” while one cell may proliferate, its neighbors …

The controls that enable melanoblasts and melanoma cells to proliferate are likely to be
related, but so far no key regulator of cell cycle progression specific to the melanocyte …

Current cancer therapies are highly toxic and often nonspecific. A potentially less toxic
approach to treating this prevalent disease employs agents that modify cancer cell …

ABSTRACT A significant portion of cellular scientific literature published is dedicated to
describing the cloning, the link to cancer, or the characterization of proteins involved in the …

Reduction in serum prostate-specific antigen (PSA) levels has been proposed as an
endpoint biomarker for hormone-refractory human prostate cancer intervention. We …