Ageing and multiple sclerosis

JS Graves, KM Krysko, LH Hua, M Absinta… - The Lancet …, 2023 - thelancet.com
The factor that is most relevant and strongly associated with the clinical course of multiple
sclerosis is chronological age. Very young patients exclusively have relapsing remitting …

Thinking outside the box: non-canonical targets in multiple sclerosis

L Bierhansl, HP Hartung, O Aktas, T Ruck… - Nature reviews Drug …, 2022 - nature.com
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …

Lactobacillus reuteri tryptophan metabolism promotes host susceptibility to CNS autoimmunity

TL Montgomery, K Eckstrom, KH Lile, S Caldwell… - Microbiome, 2022 - Springer
Background Dysregulation of gut microbiota-associated tryptophan metabolism has been
observed in patients with multiple sclerosis. However, defining direct mechanistic links …

Longitudinal multi-omics analyses link gut microbiome dysbiosis with recurrent urinary tract infections in women

CJ Worby, HL Schreiber IV, TJ Straub, LR van Dijk… - Nature …, 2022 - nature.com
Recurrent urinary tract infections (rUTIs) are a major health burden worldwide, with history of
infection being a significant risk factor. While the gut is a known reservoir for uropathogenic …

Changes in gut microbiota and multiple sclerosis: a systematic review

A Ordoñez-Rodriguez, P Roman… - International Journal of …, 2023 - mdpi.com
Introduction: Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease
mediated by autoimmune reactions against myelin proteins and gangliosides in the grey …

Limosilactobacillus reuteri in immunomodulation: molecular mechanisms and potential applications

Z Luo, A Chen, A **e, X Liu, S Jiang, R Yu - Frontiers in Immunology, 2023 - frontiersin.org
Frequent use of hormones and drugs may be associated with side-effects. Recent studies
have shown that probiotics have effects on the prevention and treatment of immune-related …

Gut-brain axis a key player to control gut dysbiosis in neurological diseases

I Pan, PK Issac, MM Rahman, A Guru… - Molecular …, 2024 - Springer
Parkinson's disease is a chronic neuropathy characterised by the formation of Lewy bodies
(misfolded alpha-synuclein) in dopaminergic neurons of the substantia nigra and other parts …

Gut–brain interactions and their impact on astrocytes in the context of multiple sclerosis and beyond

J Zißler, V Rothhammer, M Linnerbauer - Cells, 2024 - mdpi.com
Multiple Sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous
system (CNS) that leads to physical and cognitive impairment in young adults. The …

The immunomodulatory potential of short-chain fatty acids in multiple sclerosis

L Barcutean, S Maier, M Burai-Patrascu… - International Journal of …, 2024 - mdpi.com
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative central nervous
system (CNS) disorder, characterized by focal inflammation, demyelination, irreversible …

Altering the gut microbiome to potentially modulate behavioral manifestations in autism spectrum disorders: A systematic review

C Davies, D Mishra, RS Eshraghi, J Mittal… - Neuroscience & …, 2021 - Elsevier
There is a potential association between gastrointestinal (GI) symptoms and the severity of
autism spectrum disorder (ASD). Given this correlation, the possible impact of probiotics and …