Endogenous retroviruses as modulators of innate immunity

E Russ, S Iordanskiy - Pathogens, 2023 - mdpi.com
Endogenous retroviruses (ERVs), or LTR retrotransposons, are a class of transposable
elements that are highly represented in mammalian genomes. Human ERVs (HERVs) make …

Nomenclature for endogenous retrovirus (ERV) loci

RJ Gifford, J Blomberg, JM Coffin, H Fan, T Heidmann… - Retrovirology, 2018 - Springer
Retroviral integration into germline DNA can result in the formation of a vertically inherited
proviral sequence called an endogenous retrovirus (ERV). Over the course of their …

Transposable elements in mammals promote regulatory variation and diversification of genes with specialized functions

LN van de Lagemaat, JR Landry, DL Mager… - TRENDS in …, 2003 - cell.com
Nearly half of mammalian genomes are derived from ancient transposable elements (TEs).
We analyzed the prevalence of TEs in untranslated regions of human and mouse mRNAs …

[HTML][HTML] Epigenetic control of human endogenous retrovirus expression: focus on regulation of long-terminal repeats (LTRs)

TP Hurst, G Magiorkinis - Viruses, 2017 - mdpi.com
Transposable elements, including endogenous retroviruses (ERVs), comprise almost 45%
of the human genome. This could represent a significant pathogenic burden but it is …

Identification and characterization of novel human endogenous retrovirus families by phylogenetic screening of the human genome map** project database

M Tristem - Journal of virology, 2000 - journals.asm.org
Human endogenous retroviruses (HERVs) were first identified almost 20 years ago, and
since then numerous families have been described. It has, however, been difficult to obtain a …

RNAs from all categories generate retrosequences that may be exapted as novel genes or regulatory elements

J Brosius - Gene, 1999 - Elsevier
While the significance of middle repetitive elements had been neglected for a long time,
there are again tendencies to ascribe most members of a given middle repetitive sequence …

Human endogenous retrovirus K solo-LTR formation and insertional polymorphisms: implications for human and viral evolution

JF Hughes, JM Coffin - Proceedings of the National Academy of Sciences, 2004 - pnas.org
Human endogenous retroviruses (HERVs) are a potential source of genetic diversity in the
human genome. Although many of these elements have been inactivated over time by the …

Retroviruses and primate evolution

ED Sverdlov - Bioessays, 2000 - Wiley Online Library
Human endogenous retroviruses (HERVs), probably representing footprints of ancient germ‐
cell retroviral infections, occupy about 1% of the human genome. HERVs can influence …

Long terminal repeats are used as alternative promoters for the endothelin B receptor and apolipoprotein CI genes in humans

P Medstrand, JR Landry, DL Mager - Journal of Biological Chemistry, 2001 - jbc.org
To examine the potential regulatory involvement of retroelements in the human genome, we
screened the transcribed sequences of GenBank TM and expressed sequence tag data …

Genomic scrap yard: how genomes utilize all that junk

W Makałowski - Gene, 2000 - Elsevier
Interspersed repetitive sequences are major components of eukaryotic genomes. Repetitive
elements comprise over 50% of the mammalian genome. Because the specific function of …