Profiling the dysregulated immune response in sepsis: overcoming challenges to achieve the goal of precision medicine
Sepsis is characterised by a dysregulated host immune response to infection. Despite
recognition of its significance, immune status monitoring is not implemented in clinical …
recognition of its significance, immune status monitoring is not implemented in clinical …
Diagnosis of neonatal sepsis: the role of inflammatory markers
J Eichberger, E Resch, B Resch - Frontiers in Pediatrics, 2022 - frontiersin.org
This is a narrative review on the role of biomarkers in the diagnosis of neonatal sepsis. We
describe the difficulties to obtain standardized definitions in neonatal sepsis and discuss the …
describe the difficulties to obtain standardized definitions in neonatal sepsis and discuss the …
[HTML][HTML] Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections
COVID-19–associated morbidity and mortality have been attributed to a pathologic host
response. Two divergent hypotheses have been proposed: hyperinflammatory cytokine …
response. Two divergent hypotheses have been proposed: hyperinflammatory cytokine …
Endotoxin in sepsis: methods for LPS detection and the use of omics techniques
Lipopolysaccharide (LPS) or endotoxin, the major cell wall component of Gram-negative
bacteria, plays a pivotal role in the pathogenesis of sepsis. It is able to activate the host …
bacteria, plays a pivotal role in the pathogenesis of sepsis. It is able to activate the host …
Proteomic study revealed cellular assembly and lipid metabolism dysregulation in sepsis secondary to community-acquired pneumonia
Sepsis is a life-threatening disorder characterized by organ dysfunction and a major cause
of mortality worldwide. The major challenge in studying sepsis is its diversity in such factors …
of mortality worldwide. The major challenge in studying sepsis is its diversity in such factors …
Lipid metabolism impairment in patients with sepsis secondary to hospital acquired pneumonia, a proteomic analysis
Background Sepsis is a dysregulated host response to infection and a major cause of death
worldwide. Respiratory tract infections account for most sepsis cases and depending on the …
worldwide. Respiratory tract infections account for most sepsis cases and depending on the …
Glycoproteoform profiles of individual patients' plasma alpha-1-antichymotrypsin are unique and extensively remodeled following a septic episode
Sepsis and septic shock remain the leading causes of death in intensive care units (ICUs),
yet the pathogenesis originating from the inflammatory response during sepsis remains …
yet the pathogenesis originating from the inflammatory response during sepsis remains …
Multi-omics techniques make it possible to analyze sepsis-associated acute kidney injury comprehensively
J Qiao, L Cui - Frontiers in Immunology, 2022 - frontiersin.org
Sepsis-associated acute kidney injury (SA-AKI) is a common complication in critically ill
patients with high morbidity and mortality. SA-AKI varies considerably in disease …
patients with high morbidity and mortality. SA-AKI varies considerably in disease …
Proteomics reveals disturbances in the immune response and energy metabolism of monocytes from patients with septic shock
PM de Azambuja Rodrigues, RH Valente… - Scientific Reports, 2021 - nature.com
Sepsis results from a dyshomeostatic response to infection, which may lead to hyper or
hypoimmune states. Monocytes are central regulators of the inflammatory response, but our …
hypoimmune states. Monocytes are central regulators of the inflammatory response, but our …
Early diagnosis of sepsis: is an integrated omics approach the way forward?
RJ Langley, HR Wong - Molecular diagnosis & therapy, 2017 - Springer
Sepsis remains one of the leading causes of death in the USA and it is expected to get
worse as the population ages. Moreover, the standard of care, which recommends …
worse as the population ages. Moreover, the standard of care, which recommends …