Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

Response rates to immunotherapy in solid tumors remain low due in part to the elevated
prevalence of terminally exhausted T cells, a hypofunctional differentiation state induced …

Aging involves the deterioration of organismal function, leading to the emergence of multiple
pathologies. Environmental stimuli, including lifestyle, can influence the trajectory of this …

Gene regulatory effects have been difficult to detect at many non-coding loci associated with
brain-related traits, likely because some genetic variants have distinct functions in specific …

Immunocytes dynamically reprogram their gene expression profiles during differentiation
and immunoresponse. However, the underlying mechanism remains elusive. Here, we …

Secondary trastuzumab resistance represents an evolutionary adaptation of HER2‐positive
breast cancer during anti‐HER2 treatment. Most current studies have tended to prioritize …

Summary METTL14 (methyltransferase-like 14) is an RNA-binding protein that partners with
METTL3 to mediate N 6-methyladenosine (m 6 A) methylation. Recent studies identified a …

The mammalian genome is depleted in CG dinucleotides, except at protected regions where
they cluster as CpG islands (CGIs). CGIs are gene regulatory hubs and serve as …

Human pluripotent stem cells (hPSCs) are of fundamental relevance in regenerative
medicine. Naïve hPSCs hold promise to overcome some of the limitations of conventional …