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Astronaut omics and the impact of space on the human body at scale
Future multi-year crewed planetary missions will motivate advances in aerospace nutrition
and telehealth. On Earth, the Human Cell Atlas project aims to spatially map all cell types in …
and telehealth. On Earth, the Human Cell Atlas project aims to spatially map all cell types in …
[PDF][PDF] Protective alleles and precision healthcare in crewed spaceflight
Common and rare alleles are now being annotated across millions of human genomes, and
omics technologies are increasingly being used to develop health and treatment …
omics technologies are increasingly being used to develop health and treatment …
Spaceflight induces changes in gene expression profiles linked to insulin and estrogen
Organismal adaptations to spaceflight have been characterized at the molecular level in
model organisms, including Drosophila and C. elegans. Here, we extend molecular work to …
model organisms, including Drosophila and C. elegans. Here, we extend molecular work to …
Release of CD36-associated cell-free mitochondrial DNA and RNA as a hallmark of space environment response
A detailed understanding of how spaceflight affects human health is essential for long-term
space exploration. Liquid biopsies allow for minimally-invasive multi-omics assessments …
space exploration. Liquid biopsies allow for minimally-invasive multi-omics assessments …
Nitrosative Stress in Astronaut Skeletal Muscle in Spaceflight
D Blottner, M Moriggi, G Trautmann, S Furlan, K Block… - Antioxidants, 2024 - mdpi.com
Long-duration mission (LDM) astronauts from the International Space Station (ISS)(> 180
ISS days) revealed a close-to-normal sarcolemmal nitric oxide synthase type-1 (NOS1) …
ISS days) revealed a close-to-normal sarcolemmal nitric oxide synthase type-1 (NOS1) …
Redefining space pharmacology: bridging knowledge gaps in drug efficacy and safety for deep space missions
K Barchetti, A Derobertmasure, P Boutouyrie… - Frontiers in Space …, 2024 - frontiersin.org
The space environment is incredibly hostile, and humans are vulnerable in such conditions.
Astronauts encounter various stress factors during a space journey, including radiation …
Astronauts encounter various stress factors during a space journey, including radiation …
How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?
Abstract Periodically, the European Space Agency (ESA) updates scientific roadmaps in
consultation with the scientific community. The ESA SciSpacE Science Community White …
consultation with the scientific community. The ESA SciSpacE Science Community White …
[HTML][HTML] Spaceflight Induces Strength Decline in Caenorhabditis elegans
Background: Understanding and countering the well-established negative health
consequences of spaceflight remains a primary challenge preventing safe deep space …
consequences of spaceflight remains a primary challenge preventing safe deep space …
Time-resolved molecular measurements reveal changes in astronauts during spaceflight
From the early days of spaceflight to current missions, astronauts continue to be exposed to
multiple hazards that affect human health, including low gravity, high radiation, isolation …
multiple hazards that affect human health, including low gravity, high radiation, isolation …
[PDF][PDF] Spaceflight alters insulin and estrogen signaling pathways
Organismal adaptations to space ight have been characterized at the molecular level in
model organisms, including Drosophila and C. elegans. Here we extend molecular work to …
model organisms, including Drosophila and C. elegans. Here we extend molecular work to …