Spatial structure, cooperation and competition in biofilms

CD Nadell, K Drescher, KR Foster - Nature Reviews Microbiology, 2016 - nature.com
Bacteria often live within matrix-embedded communities, termed biofilms, which are now
understood to be a major mode of microbial life. The study of biofilms has revealed their vast …

Bacterial growth: a statistical physicist's guide

RJ Allen, B Waclaw - Reports on Progress in Physics, 2018 - iopscience.iop.org
Bacterial growth presents many beautiful phenomena that pose new theoretical challenges
to statistical physicists, and are also amenable to laboratory experimentation. This review …

Metabolic resource allocation in individual microbes determines ecosystem interactions and spatial dynamics

WR Harcombe, WJ Riehl, I Dukovski, BR Granger… - Cell reports, 2014 - cell.com
The interspecies exchange of metabolites plays a key role in the spatiotemporal dynamics of
microbial communities. This raises the question of whether ecosystem-level behavior of …

Cooperation, competition and antibiotic resistance in bacterial colonies

I Frost, WPJ Smith, S Mitri, AS Millan, Y Davit… - The ISME …, 2018 - academic.oup.com
Bacteria commonly live in dense and genetically diverse communities associated with
surfaces. In these communities, competition for resources and space is intense, and yet we …

Turning ecology and evolution against cancer

KS Korolev, JB Xavier, J Gore - Nature Reviews Cancer, 2014 - nature.com
The fight against cancer has drawn researchers from a wide variety of disciplines, ranging
from molecular biology to physics, but the perspective of an ecological theorist has been …

The genotypic view of social interactions in microbial communities

S Mitri, K Richard Foster - Annual review of genetics, 2013 - annualreviews.org
Dense and diverse microbial communities are found in many environments. Disentangling
the social interactions between strains and species is central to understanding microbes and …

Density of founder cells affects spatial pattern formation and cooperation in Bacillus subtilis biofilms

J Van Gestel, FJ Weissing, OP Kuipers… - The ISME …, 2014 - academic.oup.com
In nature, most bacteria live in surface-attached sedentary communities known as biofilms.
Biofilms are often studied with respect to bacterial interactions. Many cells inhabiting biofilms …

The evolution of mutualism in gut microbiota via host epithelial selection

J Schluter, KR Foster - PLoS biology, 2012 - journals.plos.org
The human gut harbours a large and genetically diverse population of symbiotic microbes
that both feed and protect the host. Evolutionary theory, however, predicts that such genetic …

Genetic drift opposes mutualism during spatial population expansion

MJI Müller, BI Neugeboren, DR Nelson… - Proceedings of the …, 2014 - pnas.org
Mutualistic interactions benefit both partners, promoting coexistence and genetic diversity.
Spatial structure can promote cooperation, but spatial expansions may also make it hard for …

Resource limitation drives spatial organization in microbial groups

S Mitri, E Clarke, KR Foster - The ISME journal, 2016 - academic.oup.com
Dense microbial groups such as bacterial biofilms commonly contain a diversity of cell types
that define their functioning. However, we have a limited understanding of what maintains, or …