Compared with transplanted tumor models or genetically engineered cancer models,
chemically induced primary malignancies in experimental animals can mimic the clinical …

Despite efforts, cancer is still one of the leading causes of morbidity and mortality worldwide,
with approximately 14 million new cases and 8.2 million cancer-related deaths each year …

Purpose To test the hypothesis that targeting the microenvironment (soil) may effectively kill
cancer cells (seeds) through a small–molecular weight sequential dual-targeting …

Metastasis is the primary cause of cancer-related mortality. Experimental models that
accurately reflect changes in metastatic burden are essential tools for develo** treatments …

Introduction Animal models play a crucial role in breast cancer research, in particular mice
and rats, who develop mammary tumors that closely resemble their human counterparts …

Preclinical models are extensively employed in cancer research because they can be
manipulated in terms of their environment, genome, molecular biology, organ systems, and …

Breast cancer is one of the most common cancers worldwide, which makes it a very
impactful malignancy in the society. Breast cancers can be classified through different …

Objectives: The present animal experiments were conducted to evaluate radioiodinated
Hypericin (Hyp) for its regional distribution as well as theranostic potentials. Materials and …

To better inform the next clinical trials of vascular disrupting agent combretastatin‐A4‐
phosphate (CA4P) in patients with hepatic malignancies, this preclinical study aimed at …

A new ditopic ligand (L) based on a 2, 2′: 5′, 4 ″-terpyridine unit substituted in the 2 ″, 6
″positions with iminodiacetate arms has been designed and synthesized for the …