Variations of human leukocyte antigen (HLA) genes in the major histocompatibility complex
region (MHC) significantly affect the risk of various diseases, especially autoimmune …

Cancer incidence and mortality rates can vary widely among different racial and ethnic
groups, attributed to a complex interplay of genetic, environmental and social factors …

Array technology to genotype single-nucleotide variants (SNVs) is widely used in genome-
wide association studies (GWAS), clinical diagnostics, and linkage studies. Arrays have …

Background Rare genetic variants cause pulmonary arterial hypertension, but the
contribution of common genetic variation to disease risk and natural history is poorly …

Inexpensive genoty** methods are essential to modern genomics. Here we present
QUILT, which performs diploid genotype imputation using low-coverage whole-genome …

Background Vancomycin is a prevalent cause of the severe hypersensitivity syndrome drug
reaction with eosinophilia and systemic symptoms (DRESS), which leads to significant …

Conventional human leukocyte antigen (HLA) imputation methods drop their performance
for infrequent alleles, which is one of the factors that reduce the reliability of trans-ethnic …

Background The introduction of HLA matching of donors and recipients was a breakthrough
in kidney transplantation. However, half of all transplanted kidneys still fail within 15 years …

The recent development of imputation methods enabled the prediction of human leukocyte
antigen (HLA) alleles from intergenic SNP data, allowing studies to fine-map HLA for …

Although many phenotypes have been associated with variants in human leukocyte antigen
(HLA) genes, the full phenotypic impact of HLA variants across all diseases is unknown. We …