Biochemistry and molecular biology of flaviviruses

NJ Barrows, RK Campos, KC Liao, KR Prasanth… - Chemical …, 2018 - ACS Publications
Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile,
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …

[HTML][HTML] Current status of Zika virus vaccines: successes and challenges

A Pattnaik, BR Sahoo, AK Pattnaik - Vaccines, 2020 - mdpi.com
The recently emerged Zika virus (ZIKV) spread to the Americas, causing a spectrum of
congenital diseases including microcephaly in newborn and Guillain-Barré syndrome (GBS) …

Recurrent potent human neutralizing antibodies to Zika virus in Brazil and Mexico

DF Robbiani, L Bozzacco, JR Keeffe, R Khouri… - Cell, 2017 - cell.com
Antibodies to Zika virus (ZIKV) can be protective. To examine the antibody response in
individuals who develop high titers of anti-ZIKV antibodies, we screened cohorts in Brazil …

Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region

I Rodriguez-Barraquer, F Costa, EJM Nascimento… - Science, 2019 - science.org
The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well
documented, but other aspects of the pandemic, such as attack rates and risk factors, are …

Intrinsic ADE: the dark side of antibody dependent enhancement during dengue infection

R Narayan, S Tripathi - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
Dengue fever is an Aedes mosquito-borne illness caused by any one of the four different
dengue virus (DENV) serotypes (1–4) and manifests in the form of symptoms ranging from …

A perspective on current flavivirus vaccine development: a brief review

SK Dutta, T Langenburg - Viruses, 2023 - mdpi.com
The flavivirus genus contains several clinically important pathogens that account for
tremendous global suffering. Primarily transmitted by mosquitos or ticks, these viruses can …

Dengue virus-reactive CD8+ T cells mediate cross-protection against subsequent Zika virus challenge

J Wen, A Elong Ngono, JA Regla-Nava, K Kim… - Nature …, 2017 - nature.com
Zika virus (ZIKV) and dengue virus (DENV) are antigenically related flaviviruses that share
cross-reactivity in antibody and T cell responses, and co-circulate in increasing numbers of …

Historical perspectives on flavivirus research

MR Holbrook - Viruses, 2017 - mdpi.com
The flaviviruses are small single-stranded RNA viruses that are typically transmitted by
mosquito or tick vectors. These “arboviruses” are found around the world and account for a …

Modulation of dengue/zika virus pathogenicity by antibody-dependent enhancement and strategies to protect against enhancement in zika virus infection

R Khandia, A Munjal, K Dhama, K Karthik… - Frontiers in …, 2018 - frontiersin.org
Antibody-dependent enhancement (ADE) is a phenomenon in which preexisting poorly
neutralizing antibodies leads to enhanced infection. It is a serious concern with mosquito …

Extracellular vesicles from Zika virus‐infected cells display viral E protein that binds ZIKV‐neutralizing antibodies to prevent infection enhancement

F Zhao, Y Xu, N Liu, D Lv, Y Chen, Z Liu, X **… - The EMBO …, 2023 - embopress.org
Mosquito‐borne flaviviruses including Zika virus (ZIKV) represent a public health problem in
some parts of the world. Although ZIKV infection is predominantly asymptomatic or …