Coumarin: A natural, privileged and versatile scaffold for bioactive compounds
Many naturally occurring substances, traditionally used in popular medicines around the
world, contain the coumarin moiety. Coumarin represents a privileged scaffold for medicinal …
world, contain the coumarin moiety. Coumarin represents a privileged scaffold for medicinal …
Proteomics, networks and connectivity indices
H González‐Díaz, Y González‐Díaz, L Santana… - …, 2008 - Wiley Online Library
Describing the connectivity of chemical and/or biological systems using networks is a
straight gate for the introduction of mathematical tools in proteomics. Networks, in some …
straight gate for the introduction of mathematical tools in proteomics. Networks, in some …
Comparative QSARs for antimalarial endochins: Importance of descriptor-thinning and noise reduction prior to feature selection
The emergence of multidrug resistance of the currently available antimalarial drugs has led
to the need of the discovery and development of new antimalarial compounds. In the present …
to the need of the discovery and development of new antimalarial compounds. In the present …
Synthesis and study of a series of 3-arylcoumarins as potent and selective monoamine oxidase B inhibitors
MJ Matos, C Teran, Y Perez-Castillo… - Journal of medicinal …, 2011 - ACS Publications
New series of 6-substituted-3-arylcoumarins displaying several alkyl, hydroxyl, halogen, and
alkoxy groups in the two benzene rings have been designed, synthesized, and evaluated in …
alkoxy groups in the two benzene rings have been designed, synthesized, and evaluated in …
New frontiers in the transition-metal-free synthesis of heterocycles from alkynoates: an overview and current status
Heterocycles are among the well-established classes of compounds, constituting a wide
range of organic molecules. These structural motifs not only have a dominant presence in a …
range of organic molecules. These structural motifs not only have a dominant presence in a …
Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins
F Chimenti, D Secci, A Bolasco… - Journal of medicinal …, 2009 - ACS Publications
A large series of 3-carboxamido-7-substituted coumarins have been synthesized and tested
in vitro for their human monoamine oxidase A and B (hMAO-A and hMAO-B) inhibitory …
in vitro for their human monoamine oxidase A and B (hMAO-A and hMAO-B) inhibitory …
Discovery and synthesis of novel 3-phenylcoumarin derivatives as antidepressant agents
A series of 3-phenylcoumarins were synthesized and screened for potential antidepressant
activity by tail suspension test (TST) in mice. Three compounds (6, 7 and 13) exhibited …
activity by tail suspension test (TST) in mice. Three compounds (6, 7 and 13) exhibited …
General theory for multiple input-output perturbations in complex molecular systems. 1. Linear QSPR electronegativity models in physical, organic, and medicinal …
H Gonzalez-Diaz, S Arrasate… - Current topics in …, 2013 - ingentaconnect.com
In general perturbation methods starts with a known exact solution of a problem and add
“small” variation terms in order to approach to a solution for a related problem without known …
“small” variation terms in order to approach to a solution for a related problem without known …
Zinc Oxide Nanoparticles as Efficient Heterogeneous Catalyst for Synthesis of Bio‐active Heterocyclic Compounds
Among the most effective recoverable catalytic systems, metal‐oxide nanoparticles (NPs)
are well known for their extensive uses in a broad range of industries, pharmaceuticals, and …
are well known for their extensive uses in a broad range of industries, pharmaceuticals, and …
General and efficient route for the synthesis of 3, 4-disubstituted coumarins via Pd-catalyzed site-selective cross-coupling reactions
L Zhang, T Meng, R Fan, J Wu - The Journal of Organic Chemistry, 2007 - ACS Publications
Palladium-catalyzed site-selective cross-coupling reactions of 3-bromo-4-trifloxycoumarin or
3-bromo-4-tosyloxycoumarin provide an efficient and facile route for the synthesis of 3, 4 …
3-bromo-4-tosyloxycoumarin provide an efficient and facile route for the synthesis of 3, 4 …