Heparin has been used extensively as an antithrombotic and anticoagulant for close to 100
years. This anticoagulant activity is attributed mainly to the pentasaccharide sequence …

The development of extracorporeal life support technology has added a new dimension to
the care of critically ill patients who fail conventional treatment options. Extracorporeal …

The activated partial thromboplastin time (APTT) assay is a very common coagulation test,
used for several reasons. The test is conventionally used for assessing the contact factor …

The alterations in the hemostatic balance in COVID‐19 patients are strongly disturbed and
contribute to a high prothrombotic status. The high rate of venous thromboembolism in …

Background Lupus anticoagulants (LA) are one laboratory criterion for classification of
antiphospholipid syndrome, with presence of vascular thrombosis and/or pregnancy/fetal …

Anticoagulant drugs (ie, unfractionated heparin, low-molecular-weight heparins, vitamin K
antagonists, and direct oral anticoagulants) are widely employed in preventing and treating …

Anticoagulant drugs comprise a specific subcategory of antithrombotic agents that act to
inhibit blood coagulation at various stages, reducing clot development and ultimately …

Antibodies against platelet factor 4 (PF4), a protein released from alpha-granules of
activated platelets, may cause a number of pathophysiological conditions. The most …

Unfractionated heparin (UFH) is the anticoagulant of choice during extracorporeal
membrane oxygenation (ECMO) support. Despite its favorable pharmacologic properties …

Anticoagulation is central to the management of thrombotic antiphospholipid syndrome
(APS). The standard anticoagulant treatment for thrombotic APS is life‐long warfarin or an …