Challenges and opportunities in NASH drug development

SA Harrison, AM Allen, J Dubourg, M Noureddin… - Nature medicine, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD) and its more severe form, nonalcoholic
steatohepatitis (NASH), represent a growing worldwide epidemic and a high unmet medical …

Nonalcoholic steatohepatitis-related hepatocellular carcinoma: pathogenesis and treatment

JM Llovet, CE Willoughby, AG Singal… - Nature reviews …, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD), including its more severe manifestation,
nonalcoholic steatohepatitis (NASH), has a global prevalence of 20–25% and is a major …

Nonalcoholic fatty liver disease and cardiovascular risk: a scientific statement from the American Heart Association

PB Duell, FK Welty, M Miller, A Chait… - … , and vascular biology, 2022 - Am Heart Assoc
Nonalcoholic fatty liver disease (NAFLD) is an increasingly common condition that is
believed to affect> 25% of adults worldwide. Unless specific testing is done to identify …

Immune cell-mediated features of non-alcoholic steatohepatitis

T Huby, EL Gautier - Nature reviews immunology, 2022 - nature.com
Non-alcoholic fatty liver disease (NAFLD) includes a range of hepatic manifestations,
starting with liver steatosis and potentially evolving towards non-alcoholic steatohepatitis …

Recompensation in cirrhosis: unravelling the evolving natural history of nonalcoholic fatty liver disease

G Feng, L Valenti, VWS Wong, YM Fouad… - Nature Reviews …, 2024 - nature.com
Recompensation has gained increasing attention in the field of cirrhosis, particularly in
chronic liver disease with a definite aetiology. The current global prevalence of obesity and …

Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis

D Hendriks, JF Brouwers, K Hamer, MH Geurts… - Nature …, 2023 - nature.com
The lack of registered drugs for nonalcoholic fatty liver disease (NAFLD) is partly due to the
paucity of human-relevant models for target discovery and compound screening. Here we …

AGA clinical practice update: diagnosis and management of nonalcoholic fatty liver disease in lean individuals: expert review

MT Long, M Noureddin, JK Lim - Gastroenterology, 2022 - Elsevier
Description Nonalcoholic fatty liver disease (NAFLD) is well recognized as a leading
etiology for chronic liver disease, affecting> 25% of the US and global populations. Up to 1 …

Breakthroughs in therapies for NASH and remaining challenges

V Ratziu, S Francque, A Sanyal - Journal of hepatology, 2022 - Elsevier
Initially a condition that received limited recognition and whose clinical impact was
controversial, non-alcoholic steatohepatitis (NASH) has become a leading cause of chronic …

[HTML][HTML] Safety and efficacy of combination therapy with semaglutide, cilofexor and firsocostat in patients with non-alcoholic steatohepatitis: A randomised, open-label …

N Alkhouri, R Herring, H Kabler, Z Kayali… - Journal of …, 2022 - Elsevier
Background & Aims Non-alcoholic steatohepatitis (NASH) is associated with increased risk
of liver-related and cardiovascular morbidity and mortality. Given the complex …