Acromegaly: pathogenesis, diagnosis, and management

M Fleseriu, F Langlois, DST Lim… - The Lancet Diabetes & …, 2022 - thelancet.com
Growth hormone-secreting pituitary adenomas that cause acromegaly arise as monoclonal
expansions of differentiated somatotroph cells and are usually sporadic. They are almost …

Personalized medical treatment of patients with acromegaly: a review

DST Lim, M Fleseriu - Endocrine Practice, 2022 - Elsevier
Acromegaly is associated with significant morbidity and mortality if it is not appropriately
treated. In addition to insulin-like growth factor 1 and growth hormone normalization as well …

Maintenance of response to oral octreotide compared with injectable somatostatin receptor ligands in patients with acromegaly: a phase 3, multicentre, randomised …

M Fleseriu, A Dreval, I Bondar, G Vagapova… - The Lancet Diabetes & …, 2022 - thelancet.com
Background Despite biochemically responding to injectable somatostatin receptor ligands
(iSRLs), many patients with acromegaly experience treatment burdens. We aimed to assess …

Global psychological assessment with the evaluation of life and sleep quality and sexual and cognitive function in a large number of patients with acromegaly: a cross …

R Pivonello, RS Auriemma… - European Journal of …, 2022 - academic.oup.com
Objective Acromegaly is associated with somatic disfigurements which impair self-
perception of well-being and quality of life. Nowadays, limited data are available on the …

Body image concerns in women with polycystic ovary syndrome: a systematic review and meta-analysis

M Davitadze, K Malhotra, H Khalil… - European Journal of …, 2023 - academic.oup.com
Objective To assess differences in body image concerns among women with and without
polycystic ovary syndrome (PCOS). Design This is a systematic review and meta-analysis …

[HTML][HTML] Evaluating the impact of acromegaly on quality of life

EC Coopmans, CD Andela, KMJA Claessen… - … and metabolism clinics …, 2022 - Elsevier
Although metabolic alterations, hypertension, and the early stages of cardiomyopathy may
be reversible after cure or disease control, many other complications such as …

The socioeconomic burden of acromegaly

S Störmann, T Cuny - European Journal of Endocrinology, 2023 - academic.oup.com
Acromegaly is a rare and insidious disease characterized by chronic excess growth
hormone, leading to various morphological changes and systemic complications. Despite its …

Treatment of acromegaly with oral octreotide

I Remba-Shapiro, LB Nachtigall - Best Practice & Research Clinical …, 2024 - Elsevier
Acromegaly is a rare disease caused by a growth hormone excess, usually due to a
secreting pituitary adenoma. Somatostatin receptor ligands (SRL) are the mainstay of …

Patient-reported outcomes in patients with acromegaly treated with pegvisomant in the ACROSTUDY extension: a real-world experience

R Salvatori, P Maffei, SM Webb, T Brue, J Loftus… - Pituitary, 2022 - Springer
Purpose To report the effects of pegvisomant (PEGV) treatment on patient-reported
outcomes in acromegaly patients. Methods We conducted an extension study of an open …

Questionnaire and tools: clinical powerful instrument in acromegaly diagnosis and management

S Camerini, A Wennberg, M Adriani, B Martin… - Journal of …, 2022 - Springer
Purpose Acromegaly is a rare chronic disease characterized by systemic comorbidity and
reduced quality of life. Although achieving biochemical control has always been the primary …