Ontogeny of hepatic transporters and drug-metabolizing enzymes in humans and in nonclinical species
BD Van Groen, J Nicolaï, AC Kuik… - Pharmacological …, 2021 - Elsevier
The liver represents a major eliminating and detoxifying organ, determining exposure to
endogenous compounds, drugs, and other xenobiotics. Drug transporters (DTs) and drug …
endogenous compounds, drugs, and other xenobiotics. Drug transporters (DTs) and drug …
INTEDE: interactome of drug-metabolizing enzymes
Drug-metabolizing enzymes (DMEs) are critical determinant of drug safety and efficacy, and
the interactome of DMEs has attracted extensive attention. There are 3 major interaction …
the interactome of DMEs has attracted extensive attention. There are 3 major interaction …
Evaluating the performance of multi-omics integration: a thyroid toxicity case study
S Canzler, K Schubert, UE Rolle-Kampczyk… - Archives of …, 2024 - Springer
Multi-omics data integration has been repeatedly discussed as the way forward to more
comprehensively cover the molecular responses of cells or organisms to chemical exposure …
comprehensively cover the molecular responses of cells or organisms to chemical exposure …
[HTML][HTML] Impact of obese levels on the hepatic expression of nuclear receptors and drug-metabolizing enzymes in adult and offspring mice
The prevalence of obesity-associated conditions raises new challenges in clinical
medication. Although altered expression of drug-metabolizing enzymes (DMEs) has been …
medication. Although altered expression of drug-metabolizing enzymes (DMEs) has been …
Epigenetic memory is involved in the persistent alterations of drug-processing genes in adult mice due to PCN-activated PXR during early life
P Wang, G Liu, Y Nie, S Han, J Li… - Toxicological …, 2019 - academic.oup.com
Pregnane X receptor (PXR), which can be activated by xenobiotic chemicals (including
pediatric drugs), plays a key role in the regulation of drug-processing genes (DPGs). The …
pediatric drugs), plays a key role in the regulation of drug-processing genes (DPGs). The …
[CITATION][C] Epigenetic mechanisms contribute to intraindividual variations of drug metabolism mediated by cytochrome P450 enzymes
[CITATION][C] Acetaminophen-induced liver injury alters expression and activities of cytochrome P450 enzymes in an age-dependent manner in mouse liver
[CITATION][C] Alterations of Cytochrome P450–Mediated Drug Metabolism during Liver Repair and Regeneration after Acetaminophen-Induced Liver Injury in Mice
[PDF][PDF] Impact of Drug-induced Liver Injury on Drug-metabolizing Cytochrome P450 Enzymes
Y Bao - archives.lib.uconn.edu
Drug therapy is an important part of the current practical medicine to treat human diseases,
but has a potential risk to develop DILI. The incidence data in several studies in various …
but has a potential risk to develop DILI. The incidence data in several studies in various …