Eukaryotic cells compartmentalize their internal milieu in order to achieve specific reactions
in time and space. This organization in distinct compartments is essential to allow …

Small ubiquitin-related modifier (SUMO) is a member of the ubiquitin-related protein family.
SUMO modulates protein function through covalent conjugation to lysine residues in a large …

Post-translational modification by Small Ubiquitin-like Modifier (SUMO) proteins regulates
numerous cellular processes. This modification involves the covalent and reversible …

Peroxisomes are organelles that carry out β-oxidation of fatty acids and amino acids. Both
rare and prevalent diseases are caused by their dysfunction. Among disease-causing …

Metabolic rewiring and redox balance play pivotal roles in cancer. Cellular senescence is a
barrier for tumorigenesis circumvented in cancer cells by poorly understood mechanisms …

PML nuclear body (NB) malfunction often leads to acute leukemia outbreaks and other
severe diseases. PML NB rescue is the molecular basis of arsenic success in acute …

In this work, we put forward a hypothesis about the decisive role of multivalent nonspecific
interactions in the early stages of PML body formation. Our analysis of the PML isoform …

Targeted therapy has become increasingly important in cancer therapy. For example,
targeting the promyelocytic leukemia PML protein in leukemia has proved to be an effective …

SUMO proteins are important regulators of many key cellular functions in part through their
ability to form interactions with other proteins containing SUMO interacting motifs (SIMs) …

Simple Summary The cell nucleus is organized into different sub-nuclear compartments to
control specific cellular processes, including PML nuclear bodies (NBs), also termed PML …