Fatty acids are metabolized and synthesized as energy substrates during biological
responses. Long-and medium-chain fatty acids derived mainly from dietary triglycerides, and …

G protein-coupled receptors (GPCRs) are historically the most successful family of drug
targets. In recent times it has become clear that the pharmacology of these receptors is far …

A high caloric intake, rich in saturated fats, greatly contributes to the development of obesity,
which is the leading risk factor for type 2 diabetes (T2D). A persistent caloric surplus …

The use of an acetylene (ethynyl) group in medicinal chemistry coincides with the launch of
the Journal of Medicinal Chemistry in 1959. Since then, the acetylene group has been …

The deorphanization of the free fatty acid (FFA) receptors FFA1 (GPR40), FFA2 (GPR43),
FFA3 (GPR41), GPR84, and GPR120 has made clear that the body is capable of …

G-protein-coupled receptors (GPCRs) are the largest class of signaling receptors that are
most frequently targeted by therapeutic drugs. Allosteric modulators bound to GPCRs at …

Label-free biosensor technology based on dynamic mass redistribution (DMR) of cellular
constituents promises to translate GPCR signaling into complex optical'fingerprints' in real …

Saturated and unsaturated free fatty acids (FFAs), as well as hydroxy carboxylic acids
(HCAs) such as lactate and ketone bodies, are carriers of metabolic energy, precursors of …

Label-free dynamic mass redistribution (DMR) is a cutting-edge assay technology that
enables real-time detection of integrated cellular responses in living cells. It relies on …

GPR120 is a receptor of unsaturated long-chain fatty acids reported to mediate GLP-1
secretion, insulin sensitization, anti-inflammatory, and anti-obesity effects and is therefore …