The Hedgehog signalling pathway has crucial roles in embryonic tissue patterning,
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …

Since their isolation in the early 1990s, members of the Hedgehog family of intercellular
signaling proteins have come to be recognized as key mediators of many fundamental …

Long, short and medium chain fatty acids are covalently attached to hundreds of proteins.
Each fatty acid confers distinct biochemical properties, enabling fatty acylation to regulate …

The Hedgehog (Hh) family of proteins control cell growth, survival, and fate, and pattern
almost every aspect of the vertebrate body plan. The use of a single morphogen for such a …

In many contexts, self-renewal and differentiation of stem cells are influenced by signals
from their environment, constituting a niche. It is postulated that stem cells compete for local …

Protein S-palmitoylation, the covalent lipid modification of the side chain of Cys residues
with the 16-carbon fatty acid palmitate, is the most common acylation of proteins in …

Wnt and Hedgehog family proteins are secreted signalling molecules (morphogens) that act
at both long and short range to control growth and patterning during development. Both …

The vast majority of eukaryotic proteins are N‐terminally modified by one or more
processing enzymes. Enzymes acting on the very first amino acid of a polypeptide include …

A wide variety of signaling proteins are modified by covalently linked fatty acids and/or
prenyl groups. These hydrophobic moieties, which include myristate, palmitate, farnesyl and …

One of the most dominant influences in the patterning of multicellular embryos is exerted by
the Hedgehog (Hh) family of secreted signaling proteins. Here, we identify a segment …