Hexokinases are a family of ubiquitous exose-phosphorylating enzymes that prime glucose
for intracellular utilization. Hexokinase 2 (HK2) is the most active isozyme of the family …

The mitochondrial permeability transition (PT) is a permeability increase of the inner
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …

Oxidative stress basically defines a condition in which prooxidant–antioxidant balance in the
cell is disturbed; cellular biomolecules undergo severe oxidative damage, ultimately …

Stroke is the leading cause of death and physical disability worldwide. Mitochondrial
dysfunction has been considered as one of the hallmarks of ischemic stroke and contributes …

Purpose of Review Mitochondria are recognized to be one of the most important organelles
in chondrocytes for their role in triphosphate (ATP) generation through aerobic …

Parkinson's disease is a pervasive, ageing-related neurodegenerative disease the cardinal
motor symptoms of which reflect the loss of a small group of neurons, the dopaminergic …

Reactive oxygen species (ROS) are highly reactive molecules, mainly generated inside
mitochondria that can oxidize DNA, proteins, and lipids. At physiological levels, ROS …

The permeability transition in human mitochondria refers to the opening of a nonspecific
channel, known as the permeability transition pore (PTP), in the inner membrane. Opening …

Because of its unique function and anatomical location, the liver is exposed to a multitude of
toxins and xenobiotics, including medications and alcohol, as well as to infection by …

The link between chronic psychosocial and metabolic stress and the pathogenesis of
disease has been extensively documented. Nevertheless, the cellular mechanisms by which …