[HTML][HTML] Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity
Canonically, gasdermin D (GSDMD) cleavage by caspase-1 through inflammasome
signaling triggers immune cell pyroptosis (ICP) as a host defense against pathogen …
signaling triggers immune cell pyroptosis (ICP) as a host defense against pathogen …
Toward targeting inflammasomes: insights into their regulation and activation
Inflammasomes are multi-component signaling complexes critical to the initiation of
pyroptotic cell death in response to invading pathogens and cellular damage. A number of …
pyroptotic cell death in response to invading pathogens and cellular damage. A number of …
Alterations of p63 and p73 in human cancers
K Inoue, EA Fry - Mutant p53 and MDM2 in Cancer, 2014 - Springer
Abstract p53 and its related genes, p63 and p73 constitute the p53 gene family. While p53 is
the most frequently mutated gene in human tumors, p63 and p73 are rarely mutated or …
the most frequently mutated gene in human tumors, p63 and p73 are rarely mutated or …
Gasdermins and cancers
The identification of gasdermin as the executor of pyroptosis has opened new avenues for
the study of this process. Although pyroptosis research has mainly focused on immune cells …
the study of this process. Although pyroptosis research has mainly focused on immune cells …
[HTML][HTML] Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities
The ubiquitin proteasome system (UPS) plays a role in the regulation of most cellular
pathways, and its deregulation has been implicated in a wide range of human pathologies …
pathways, and its deregulation has been implicated in a wide range of human pathologies …
Context is everything: extrinsic signalling and gain-of-function p53 mutants
The TP53 genomic locus is a target of mutational events in at least half of cancers. Despite
several decades of study, a full consensus on the relevance of the acquisition of p53 gain-of …
several decades of study, a full consensus on the relevance of the acquisition of p53 gain-of …
[HTML][HTML] Caspase-1 activity is required for UVB-induced apoptosis of human keratinocytes
G Sollberger, GE Strittmatter, S Grossi… - Journal of Investigative …, 2015 - Elsevier
Caspase-1 has a crucial role in innate immunity as the protease activates the
proinflammatory cytokine prointerleukin (IL)-1β. Furthermore, caspase-1 induces pyroptosis …
proinflammatory cytokine prointerleukin (IL)-1β. Furthermore, caspase-1 induces pyroptosis …
[HTML][HTML] A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression
L Zhang, J Zhang, X Xuan, D Wu, J Yu, P Wang… - Cell Reports, 2023 - cell.com
The p53 tumor suppressor exerts antitumor functions through its ability to regulate the
transcription of its downstream targets. Long noncoding RNAs (lncRNAs) act as oncogenes …
transcription of its downstream targets. Long noncoding RNAs (lncRNAs) act as oncogenes …
A double dealing tale of p63: an oncogene or a tumor suppressor
Y Chen, Y Peng, S Fan, Y Li, ZX **ao, C Li - Cellular and Molecular Life …, 2018 - Springer
As a member of tumor suppressor p53 family, p63, a gene encoding versatile protein variant,
has been documented to correlate with cancer formation and progression, though it is rarely …
has been documented to correlate with cancer formation and progression, though it is rarely …
[HTML][HTML] Multiple roles of p53 in cancer development: Regulation of tumor microenvironment, m6A modification and diverse cell death mechanisms
X Wang, J Yang, W Yang, H Sheng, B Jia… - Journal of Advanced …, 2024 - Elsevier
Background The protein p53, encoded by the most frequently mutated gene TP53 in human
cancers, has diverse functions in tumor suppression. As a best known transcription factor …
cancers, has diverse functions in tumor suppression. As a best known transcription factor …