Direct effects of thyroid hormones on hepatic lipid metabolism

RA Sinha, BK Singh, PM Yen - Nature Reviews Endocrinology, 2018 - nature.com
It has been known for a long time that thyroid hormones have prominent effects on hepatic
fatty acid and cholesterol synthesis and metabolism. Indeed, hypothyroidism has been …

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

RJ Perry, VT Samuel, KF Petersen, GI Shulman - Nature, 2014 - nature.com
Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance
and type 2 diabetes, are rapidly growing epidemics, which lead to increased morbidity and …

Roles of diacylglycerols and ceramides in hepatic insulin resistance

MC Petersen, GI Shulman - Trends in pharmacological sciences, 2017 - cell.com
Although ample evidence links hepatic lipid accumulation with hepatic insulin resistance,
the mechanistic basis of this association is incompletely understood and controversial …

Nonalcoholic fatty liver disease and hypercholesterolemia: roles of thyroid hormones, metabolites, and agonists

RA Sinha, E Bruinstroop, BK Singh, PM Yen - Thyroid, 2019 - liebertpub.com
Background: Thyroid hormones (THs) exert a strong influence on mammalian lipid
metabolism at the systemic and hepatic levels by virtue of their roles in regulating circulating …

Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link?

M Asrih, FR Jornayvaz - Molecular and cellular endocrinology, 2015 - Elsevier
Metabolic syndrome (MetS) is a disease composed of different risk factors such as obesity,
type 2 diabetes or dyslipidemia. The prevalence of this syndrome is increasing worldwide in …

The role of thyroid hormone in metabolism and metabolic syndrome

PFS Teixeira, PB Dos Santos… - … in endocrinology and …, 2020 - journals.sagepub.com
Metabolic syndrome (MetS) and thyroid dysfunction are common in clinical practice. The
objectives of this review are to discuss some proposed mechanisms by which thyroid …

Thyroid hormones in diabetes, cancer, and aging

BR Gauthier, A Sola‐García, MÁ Cáliz‐Molina… - Aging cell, 2020 - Wiley Online Library
Thyroid function is central in the control of physiological and pathophysiological processes.
Studies in animal models and human research have determined that thyroid hormones …

Thyroid hormones and the metabolic syndrome

KA Iwen, E Schröder, G Brabant - European thyroid journal, 2013 - etj.bioscientifica.com
Background: Clustering of various metabolic parameters including abdominal obesity,
hyperglycaemia, low high-density lipoprotein cholesterol, elevated triglycerides and …

Important hormones regulating lipid metabolism

D Zhang, Y Wei, Q Huang, Y Chen, K Zeng, W Yang… - Molecules, 2022 - mdpi.com
There is a wide variety of kinds of lipids, and complex structures which determine the
diversity and complexity of their functions. With the basic characteristic of water insolubility …

Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance

FR Jornayvaz, GI Shulman - Cell metabolism, 2012 - cell.com
Nonalcoholic fatty liver disease (NAFLD) is now the most frequent chronic liver disease in
Western societies, affecting one in four adults in the USA, and is strongly associated with …