Introduction. One in eight of all total hip replacements requires revision within 10 years, 60%
because of wear-related complications. The bearing surfaces may be made of …

Hip arthroplasty can be considered one of the major successes of orthopedic surgery, with
more than 350000 replacements performed every year in the United States with a constantly …

Occupational and environmental exposure to Co and Cr has been previously linked to a
wide array of inflammatory and degenerative conditions and cancer. Recently, significant …

Adverse Local Tissue Reactions (ALTRs) are one of the main causes of hip implant failures.
Although the metal release from the implants is considered as a main etiology, the …

Progress made in the last two decades in chemical vapour deposition technology has
enabled the production of inexpensive, high-quality coatings made from diamond to become …

The performance of total joint arthroplasty (TJA) depends on the size/shape, material, and
amounts of implant debris. Much remains unknown in terms of which types of debris are …

Increased failure rates due to metallic wear particle-associated adverse local tissue
reactions (ALTR) is a significant clinical problem in resurfacing and total hip arthroplasty …

Recently, nanometre-sized UHMWPE particles generated from hip and knee replacements
have been identified in vitro and in vivo. UHMWPE particles in the 0.1–1.0 μm size range …

The objective of Part I of this analysis was to identify the relevant physicochemical
characteristics of wear particles from cobalt-chromium alloy (CoCr) metal-on-metal (MoM) …

Nanotechnology holds the promise of novel and more effective treatments for vexing human
health issues. Among these are the use of nanoparticle platforms for site-specific delivery of …