3D chromatin architecture and transcription regulation in cancer
Chromatin has distinct three-dimensional (3D) architectures important in key biological
processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn …
processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn …
Enhancer RNAs (eRNAs) in cancer: the jacks of all trades
S Napoli, N Munz, F Guidetti, F Bertoni - Cancers, 2022 - mdpi.com
Simple Summary This review focuses on eRNAs and the several mechanisms by which they
can regulate gene expression. In particular we describe here the most recent examples of …
can regulate gene expression. In particular we describe here the most recent examples of …
A SWI/SNF-dependent transcriptional regulation mediated by POU2AF2/C11orf53 at enhancer
Recent studies have identified a previously uncharacterized protein C11orf53 (now named
POU2AF2/OCA-T1), which functions as a robust co-activator of POU2F3, the master …
POU2AF2/OCA-T1), which functions as a robust co-activator of POU2F3, the master …
[HTML][HTML] Recapitulation of patient-specific 3D chromatin conformation using machine learning
D Xu, AN Forbes, S Cohen, A Palladino… - Cell reports …, 2023 - cell.com
Regulatory networks containing enhancer-gene edges define cellular states. Multiple efforts
have revealed these networks for reference tissues and cell lines by integrating multi-omics …
have revealed these networks for reference tissues and cell lines by integrating multi-omics …
Epigenetic remodelling of enhancers in response to estrogen deprivation and re-stimulation
A Sklias, A Halaburkova, L Vanzan… - Nucleic Acids …, 2021 - academic.oup.com
Estrogen hormones are implicated in a majority of breast cancers and estrogen receptor
alpha (ER), the main nuclear factor mediating estrogen signaling, orchestrates a complex …
alpha (ER), the main nuclear factor mediating estrogen signaling, orchestrates a complex …
A large Canadian cohort provides insights into the genetic architecture of human hair colour
Hair colour is a polygenic phenotype that results from differences in the amount and ratio of
melanins located in the hair bulb. Genome-wide association studies (GWAS) have identified …
melanins located in the hair bulb. Genome-wide association studies (GWAS) have identified …
Recapitulation of patient-specific 3D chromatin conformation using machine learning and validation of identified enhancer-gene targets
D Xu, AN Forbes, S Cohen, A Palladino… - bioRxiv, 2021 - biorxiv.org
Regulatory networks containing enhancer to gene edges define cellular state and their
rewiring is a hallmark of cancer. While efforts, such as ENCODE, have revealed these …
rewiring is a hallmark of cancer. While efforts, such as ENCODE, have revealed these …
Interplay between regulatory elements and chromatin topology in cellular lineage determination
V Shukla, A Cetnarowska, M Hyldahl, S Mandrup - Trends in Genetics, 2022 - cell.com
Cellular lineage determination is controlled by combinations of lineage-selective
transcription factors (TFs) and associated coregulators that bind to cis-regulatory elements in …
transcription factors (TFs) and associated coregulators that bind to cis-regulatory elements in …
CARATTERIZZAZIONE DEI MECCANISMI MOLECOLARI CHE CONTROLLANO L'ESPRESSIONE DI GENI INFIAMMATORI NEI MACROFAGI
F Cilenti - 2021 - iris.unisr.it
Tight control of inflammatory gene expression by antagonistic environmental cues, namely
immunostimulatory and immunomodulatory, ensures immune protection and avoid tissue …
immunostimulatory and immunomodulatory, ensures immune protection and avoid tissue …
The identification and interpretation of pathogenic non-coding mutations in pancreatic ductal adenocarcinoma.
M Patel - 2021 - qmro.qmul.ac.uk
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and lethal
malignancies. Despite significant advances in medicine and surgery, pancreatic cancer still …
malignancies. Despite significant advances in medicine and surgery, pancreatic cancer still …