[HTML][HTML] Methods for ChIP-seq analysis: A practical workflow and advanced applications
R Nakato, T Sakata - Methods, 2021 - Elsevier
Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is a central method in
epigenomic research. Genome-wide analysis of histone modifications, such as enhancer …
epigenomic research. Genome-wide analysis of histone modifications, such as enhancer …
Undisclosed, unmet and neglected challenges in multi-omics studies
Multi-omics approaches have become a reality in both large genomics projects and small
laboratories. However, the multi-omics research community still faces a number of issues …
laboratories. However, the multi-omics research community still faces a number of issues …
[HTML][HTML] Loss of epigenetic information as a cause of mammalian aging
All living things experience an increase in entropy, manifested as a loss of genetic and
epigenetic information. In yeast, epigenetic information is lost over time due to the …
epigenetic information. In yeast, epigenetic information is lost over time due to the …
PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma
The PDCD1-encoded immune checkpoint receptor PD-1 is a key tumor suppressor in T cells
that is recurrently inactivated in T cell non-Hodgkin lymphomas (T-NHLs). The highest …
that is recurrently inactivated in T cell non-Hodgkin lymphomas (T-NHLs). The highest …
[HTML][HTML] Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring
A father's lifestyle impacts offspring health; yet, the underlying molecular mechanisms
remain elusive. We hypothesized that a diet that changes methyl donor availability will alter …
remain elusive. We hypothesized that a diet that changes methyl donor availability will alter …
INX-315, a selective CDK2 inhibitor, induces cell cycle arrest and senescence in solid tumors
C Dietrich, A Trub, A Ahn, M Taylor, K Ambani… - Cancer discovery, 2024 - AACR
Abstract Cyclin-dependent kinase 2 (CDK2) is thought to play an important role in driving
proliferation of certain cancers, including those harboring CCNE1 amplification and breast …
proliferation of certain cancers, including those harboring CCNE1 amplification and breast …
Acetyl-methyllysine marks chromatin at active transcription start sites
WJ Lu-Culligan, LJ Connor, Y **e, BE Ekundayo… - Nature, 2023 - nature.com
Lysine residues in histones and other proteins can be modified by post-translational
modifications that encode regulatory information. Lysine acetylation and methylation are …
modifications that encode regulatory information. Lysine acetylation and methylation are …
Aging human hematopoietic stem cells manifest profound epigenetic reprogramming of enhancers that may predispose to leukemia
ER Adelman, HT Huang, A Roisman, A Olsson… - Cancer discovery, 2019 - AACR
Aging is associated with functional decline of hematopoietic stem cells (HSC) as well as an
increased risk of myeloid malignancies. We performed an integrative characterization of …
increased risk of myeloid malignancies. We performed an integrative characterization of …
CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity
Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) were designed to
induce cancer cell cycle arrest. Recent studies have suggested that these agents also exert …
induce cancer cell cycle arrest. Recent studies have suggested that these agents also exert …
[HTML][HTML] ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitization
ATRX, a chromatin remodeler protein, is recurrently mutated in H3F3A-mutant pediatric
glioblastoma (GBM) and isocitrate dehydrogenase (IDH)-mutant grade 2/3 adult glioma …
glioblastoma (GBM) and isocitrate dehydrogenase (IDH)-mutant grade 2/3 adult glioma …