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Drug‐induced liver injury: clinical evidence of N‐acetyl cysteine protective effects
Oxidative stress is a key pathological feature implicated in both acute and chronic liver
diseases, including drug‐induced liver injury (DILI). The latter describes hepatic injury …
diseases, including drug‐induced liver injury (DILI). The latter describes hepatic injury …
Development and characterization of Polycaprolactone/chitosan-based scaffolds for tissue engineering of various organs: A review
Research in creating 3D structures mirroring the extracellular matrix (ECM) with accurate
environmental cues holds paramount significance in biological applications. Biomaterials …
environmental cues holds paramount significance in biological applications. Biomaterials …
[HTML][HTML] Single-cell transcriptomics identifies gene expression networks driving differentiation and tumorigenesis in the human fallopian tube
The human fallopian tube harbors the cell of origin for the majority of high-grade serous"
ovarian" cancers (HGSCs), but its cellular composition, particularly the epithelial component …
ovarian" cancers (HGSCs), but its cellular composition, particularly the epithelial component …
[HTML][HTML] In vitro liver toxicity testing of chemicals: a pragmatic approach
A Tabernilla, B dos Santos Rodrigues… - International journal of …, 2021 - mdpi.com
The liver is among the most frequently targeted organs by noxious chemicals of diverse
nature. Liver toxicity testing using laboratory animals not only raises serious ethical …
nature. Liver toxicity testing using laboratory animals not only raises serious ethical …
In vivo and in vitro models of hepatocellular carcinoma: current strategies for translational modeling
Simple Summary Hepatocellular carcinoma (HCC) is a highly incident and deadly malignant
neoplasia, and only a few anti-HCC drugs are currently available. Thus, the development of …
neoplasia, and only a few anti-HCC drugs are currently available. Thus, the development of …
Sex difference in liver diseases: How preclinical models help to dissect the sex-related mechanisms sustaining NAFLD and hepatocellular carcinoma
Only a few preclinical findings are confirmed in the clinic, posing a critical issue for clinical
development. Therefore, identifying the best preclinical models can help to dissect …
development. Therefore, identifying the best preclinical models can help to dissect …
Zwitterion-doped liquid crystal speckle reducers for immersive displays and vectorial imaging
Lasers possess many attractive features (eg, high brightness, narrow linewidth, well-defined
polarization) that make them the ideal illumination source for many different scientific and …
polarization) that make them the ideal illumination source for many different scientific and …
Hepatotoxicity induced by nanomaterials: mechanisms and in vitro models
The unique physicochemical properties of materials at nanoscale have opened a plethora of
opportunities for applications in the pharmaceutical and medical field, but also in consumer …
opportunities for applications in the pharmaceutical and medical field, but also in consumer …
[HTML][HTML] Setup of human liver-chips integrating 3D models, microwells and a standardized microfluidic platform as proof-of-concept study to support drug evaluation
B Cox, P Barton, R Class, H Coxhead… - Biomaterials and …, 2022 - Elsevier
Human 3D liver microtissues/spheroids are powerful in vitro models to study drug-induced
liver injury (DILI) but the small number of cells per spheroid limits the models' usefulness to …
liver injury (DILI) but the small number of cells per spheroid limits the models' usefulness to …
[HTML][HTML] Cholestatic liver injury induced by food additives, dietary supplements and parenteral nutrition
Cholestasis refers to the accumulation of toxic levels of bile acids in the liver due to defective
bile secretion. This pathological situation can be triggered by drugs, but also by ingredients …
bile secretion. This pathological situation can be triggered by drugs, but also by ingredients …