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Treating cognitive impairment in schizophrenia with GLP-1RAs: an overview of their therapeutic potential
Introduction Schizophrenia is a neuropsychiatric disorder that affects approximately 1% of
individuals worldwide. There are no available medications to treat cognitive impairment in …
individuals worldwide. There are no available medications to treat cognitive impairment in …
Human stem cell-based models to study synaptic dysfunction and cognition in schizophrenia: A narrative review
S Santarriaga, K Gerlovin, Y Layadi… - Schizophrenia …, 2023 - Elsevier
Cognitive impairment is the strongest predictor of functional outcomes in schizophrenia and
is hypothesized to result from synaptic dysfunction. However, targeting synaptic plasticity …
is hypothesized to result from synaptic dysfunction. However, targeting synaptic plasticity …
Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by hemizygosity of the psychiatric risk gene Cacna1c
CM Tigaret, TCE Lin, ER Morrell, L Sykes… - Molecular …, 2021 - nature.com
Genetic variation in CACNA1C, which encodes the alpha-1 subunit of CaV1. 2 L-type
voltage-gated calcium channels, is strongly linked to risk for psychiatric disorders including …
voltage-gated calcium channels, is strongly linked to risk for psychiatric disorders including …
Effects of Cacna1c haploinsufficiency on social interaction behavior and 50-kHz ultrasonic vocalizations in adult female rats
The risk gene CACNA1C is strongly implicated in the etiology of all major psychiatric
disorders, such as depressive disorder, bipolar disorder, autism spectrum disorder, and …
disorders, such as depressive disorder, bipolar disorder, autism spectrum disorder, and …
[HTML][HTML] Mutational landscape of autism spectrum disorder brain tissue
Rare post-zygotic mutations in the brain are now known to contribute to several
neurodevelopmental disorders, including autism spectrum disorder (ASD). However, due to …
neurodevelopmental disorders, including autism spectrum disorder (ASD). However, due to …
A next generation sequencing gene panel for use in the diagnosis of anorexia nervosa
MR Ceccarini, V Precone, E Manara, S Paolacci… - Eating and Weight …, 2021 - Springer
Purpose The aim of this study was to increase knowledge of genes associated with anorexia
nervosa (AN) and their diagnostic offer, using a next generation sequencing (NGS) panel for …
nervosa (AN) and their diagnostic offer, using a next generation sequencing (NGS) panel for …
Long-term environmental impact on object recognition, spatial memory and reversal learning capabilities in Cacna1c-haploinsufficient rats
Genetic and environmental influences are thought to interact in their contribution to the
etiology of major neuropsychiatric disorders. One of the best replicated findings obtained in …
etiology of major neuropsychiatric disorders. One of the best replicated findings obtained in …
[HTML][HTML] Cognitive inflexibility, obsessive-compulsive symptoms and traits and poor post-pandemic adjustment.
L Pellegrini, NA Fineberg - Neuroscience Applied, 2024 - Elsevier
The ability to flexibly adapt thoughts and behaviours represents a fundamental attribute for
behavioural success. Impairments in aspects of cognitive flexibility are found as …
behavioural success. Impairments in aspects of cognitive flexibility are found as …
The role of rodent behavioral models of schizophrenia in the ongoing search for novel antipsychotics
H Cano-Ramírez, KL Hoffman - Expert Opinion on Drug Discovery, 2025 - Taylor & Francis
Introduction Existing pharmacotherapies for schizophrenia have not progressed beyond
targeting dopamine and serotonin neurotransmission. Rodent models of schizophrenia are …
targeting dopamine and serotonin neurotransmission. Rodent models of schizophrenia are …
The importance of common currency tasks in translational psychiatry
Abstract Purpose of Review Common currency tasks are tasks that investigate the same
phenomenon in different species. In this review, we discuss how to ensure the translational …
phenomenon in different species. In this review, we discuss how to ensure the translational …