Treating cognitive impairment in schizophrenia with GLP-1RAs: an overview of their therapeutic potential

J Flintoff, JP Kesby, D Siskind… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction Schizophrenia is a neuropsychiatric disorder that affects approximately 1% of
individuals worldwide. There are no available medications to treat cognitive impairment in …

Human stem cell-based models to study synaptic dysfunction and cognition in schizophrenia: A narrative review

S Santarriaga, K Gerlovin, Y Layadi… - Schizophrenia …, 2023 - Elsevier
Cognitive impairment is the strongest predictor of functional outcomes in schizophrenia and
is hypothesized to result from synaptic dysfunction. However, targeting synaptic plasticity …

Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by hemizygosity of the psychiatric risk gene Cacna1c

CM Tigaret, TCE Lin, ER Morrell, L Sykes… - Molecular …, 2021 - nature.com
Genetic variation in CACNA1C, which encodes the alpha-1 subunit of CaV1. 2 L-type
voltage-gated calcium channels, is strongly linked to risk for psychiatric disorders including …

Effects of Cacna1c haploinsufficiency on social interaction behavior and 50-kHz ultrasonic vocalizations in adult female rats

TM Redecker, TM Kisko, RKW Schwarting… - Behavioural brain …, 2019 - Elsevier
The risk gene CACNA1C is strongly implicated in the etiology of all major psychiatric
disorders, such as depressive disorder, bipolar disorder, autism spectrum disorder, and …

[HTML][HTML] Mutational landscape of autism spectrum disorder brain tissue

M Woodbury-Smith, S Lamoureux, G Begum, N Nassir… - Genes, 2022 - mdpi.com
Rare post-zygotic mutations in the brain are now known to contribute to several
neurodevelopmental disorders, including autism spectrum disorder (ASD). However, due to …

A next generation sequencing gene panel for use in the diagnosis of anorexia nervosa

MR Ceccarini, V Precone, E Manara, S Paolacci… - Eating and Weight …, 2021 - Springer
Purpose The aim of this study was to increase knowledge of genes associated with anorexia
nervosa (AN) and their diagnostic offer, using a next generation sequencing (NGS) panel for …

Long-term environmental impact on object recognition, spatial memory and reversal learning capabilities in Cacna1c-haploinsufficient rats

MD Braun, TM Kisko, SH Witt… - Human Molecular …, 2019 - academic.oup.com
Genetic and environmental influences are thought to interact in their contribution to the
etiology of major neuropsychiatric disorders. One of the best replicated findings obtained in …

[HTML][HTML] Cognitive inflexibility, obsessive-compulsive symptoms and traits and poor post-pandemic adjustment.

L Pellegrini, NA Fineberg - Neuroscience Applied, 2024 - Elsevier
The ability to flexibly adapt thoughts and behaviours represents a fundamental attribute for
behavioural success. Impairments in aspects of cognitive flexibility are found as …

The role of rodent behavioral models of schizophrenia in the ongoing search for novel antipsychotics

H Cano-Ramírez, KL Hoffman - Expert Opinion on Drug Discovery, 2025 - Taylor & Francis
Introduction Existing pharmacotherapies for schizophrenia have not progressed beyond
targeting dopamine and serotonin neurotransmission. Rodent models of schizophrenia are …

The importance of common currency tasks in translational psychiatry

AC Pike, M Lowther, OJ Robinson - Current Behavioral Neuroscience …, 2021 - Springer
Abstract Purpose of Review Common currency tasks are tasks that investigate the same
phenomenon in different species. In this review, we discuss how to ensure the translational …