Azithromycin is a macrolide antibiotic which inhibits bacterial protein synthesis, quorum-
sensing and reduces the formation of biofilm. Accumulating effectively in cells, particularly …

Introduction: Lipophilicity, expressed as the octanol-water partition coefficient, constitutes the
most important property in drug action, influencing both pharmacokinetic and …

Many chemicals accumulate in organisms through a variety of different mechanisms.
Cationic amphiphilic drugs (CADs) accumulate in lysosomes and bind to membranes …

Introduction: The development of immobilized artificial membrane (IAM) chromatography
has unfolded new perspectives for the use of chromatographic techniques in drug discovery …

Azithromycin is a macrolide antibiotic with well-described anti-inflammatory properties which
can be attributed, at least partially, to its action on macrophages. We have previously shown …

Per-and polyfluoroalkyl substances (PFAS) are a group of human-made compounds with
strong CF bonds, and have been used in various manufacturing industries for decades …

Macrolide antibiotics are known to exert anti-inflammatory actions in vivo, including certain
effects in COPD patients. In order to investigate the immunomodulatory profile of activity of …

Introduction: Natural products have long been instrumental for discovering antibiotics, but
many pharmaceutical companies abandoned this field and new antibiotics declined. In …

Macrolides are widely used for the long-term treatment of infections and chronic
inflammatory diseases. The pharmacokinetic features of macrolides include extensive tissue …

Characterizing the properties of large numbers of compounds and estimating their potential
absorption, distribution, metabolism and elimination properties are important early stages in …