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Counter-regulatory renin–angiotensin system in cardiovascular disease
The renin–angiotensin system is an important component of the cardiovascular system.
Mounting evidence suggests that the metabolic products of angiotensin I and II—initially …
Mounting evidence suggests that the metabolic products of angiotensin I and II—initially …
Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
The renin-angiotensin system: going beyond the classical paradigms
Thirty years ago, a novel axis of the renin-angiotensin system (RAS) was unveiled by the
discovery of angiotensin-(1− 7)[ANG-(1− 7)] generation in vivo. Later, angiotensin …
discovery of angiotensin-(1− 7)[ANG-(1− 7)] generation in vivo. Later, angiotensin …
The angiotensin AT2 receptor: from a binding site to a novel therapeutic target
Discovered more than 30 years ago, the angiotensin AT 2 receptor (AT 2 R) has evolved
from a binding site with unknown function to a firmly established major effector within the …
from a binding site with unknown function to a firmly established major effector within the …
Targeting the renin-angiotensin-aldosterone system in fibrosis
Fibrosis is characterized by excessive deposition of extracellular matrix components such as
collagen in tissues or organs. Fibrosis can develop in the heart, kidneys, liver, skin or any …
collagen in tissues or organs. Fibrosis can develop in the heart, kidneys, liver, skin or any …
The comparative efficacy and safety of the angiotensin receptor blockers in the management of hypertension and other cardiovascular diseases
All national guidelines for the management of hypertension recommend angiotensin
receptor blockers (ARBs) as an initial or add-on antihypertensive therapy. The eight …
receptor blockers (ARBs) as an initial or add-on antihypertensive therapy. The eight …
Angiotensin II type 2 receptor: a target for protection against hypertension, metabolic dysfunction, and organ remodeling
The renin-angiotensin system is of vital significance not only in the maintenance of blood
pressure but also because of its role in the pathophysiology of different organ systems in the …
pressure but also because of its role in the pathophysiology of different organ systems in the …
[HTML][HTML] AT2 receptors in cardiovascular and renal diseases
The renin-angiotensin system (RAS) plays an important role in the initiation and progression
of cardiovascular and renal diseases. These actions mediated by AT1 receptor (AT1R) are …
of cardiovascular and renal diseases. These actions mediated by AT1 receptor (AT1R) are …
[HTML][HTML] Low-dose empagliflozin improves systolic heart function after myocardial infarction in rats: regulation of MMP9, NHE1, and SERCA2a
J Goerg, M Sommerfeld, B Greiner, D Lauer… - International Journal of …, 2021 - mdpi.com
The effects of the selective sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin
in low dose on cardiac function were investigated in normoglycemic rats. Cardiac …
in low dose on cardiac function were investigated in normoglycemic rats. Cardiac …
Baicalein ameliorates myocardial ischemia through reduction of oxidative stress, inflammation and apoptosis via TLR4/MyD88/MAPKS/NF-κB pathway and regulation …
J Li, Y Yang, H Wang, D Ma, H Wang, L Chu… - Frontiers in …, 2022 - frontiersin.org
Background: Baicalein (Bai) is the principal ingredient of Scutellaria baicalensis Georgi.
Reports concerning the therapeutic advantages in treating cardiovascular diseases have …
Reports concerning the therapeutic advantages in treating cardiovascular diseases have …