The treatment of bacterial diseases is facing twin threats, with increasing bacterial antibiotic
resistance and relatively few novel compounds or strategies under development or entering …

Host-defense peptides (HDPs) are vital components of innate immunity in all vertebrates.
While their antibacterial activity toward bacterial cells was the original focus for research …

Background Sepsis involves aberrant immune responses to infection, but the exact nature of
this immune dysfunction remains poorly defined. Bacterial endotoxins like …

Sepsis is common, often fatal and requires rapid interventions to improve outcomes. While
the optimal management of sepsis in the intensive care setting is the focus of extensive …

The complexity of treating severe sepsis and septic shock has been elucidated in myriad
studies, particularly in the past 10 years. The development of clinical guidelines, insight into …

Despite extensive research on candidate pharmacological treatments and a significant and
increasing prevalence, sepsis syndrome, and acute respiratory distress syndrome (ARDS) …

Despite numerous advances in medical treatment, sepsis remains one of the leading causes
of death worldwide. Sepsis is characterized by the involvement of all organs and tissues as …

The aim of this phase 1 clinical trial was to test the safety and feasibility of a single dose of
allogeneic umbilical cord-derived mesenchymal stem cells (MSCs) in patients with severe …

Neonates, especially those born preterm, are at increased risk of sepsis and adverse long-
term effects associated with infection-related inflammation. Distinct neonatal immune …

Sepsis is one of the most common causes of morbidity and mortality worldwide. Despite the
remarkable advances in modern medicine throughout the last century, the mortality rates …