For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional
concepts in toxicology, in particular the dogma of “the dose makes the poison,” because …

This review compiles and evaluates existing scientific information on the use, limitations,
and procedural considerations for EROD activity (a catalytic measurement of cytochrome …

Background Bifidobacterium longum subsp. infantis (B. infantis) is a commensal bacterium
that colonizes the gastrointestinal tract of breast-fed infants. B. infantis can efficiently utilize …

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental carcinogens and
metabolized by a variety of xenobiotic-metabolizing enzymes such as cytochrome P450 …

Endocrine-disrupting chemicals (EDCs) are exogenous agents with the ability to interfere
with processes regulated by endogenous hormones. One such process is female …

The aryl hydrocarbon (or dioxin) receptor (AhR) is a ligand-activated basic helix-loop-helix
(bHLH) protein that heterodimerizes with the bHLH protein ARNT (aryl hydrocarbon nuclear …

The aryl hydrocarbon receptor (Ah receptor or AHR) is a ligand-activated transcription factor
involved in the regulation of several genes, including those for xenobiotic-metabolizing …

Numerous members of the cytochrome P450 (CYP) superfamily are induced after exposure
to a variety of xenobiotics in human liver. We have gained considerable mechanistic insights …

NF-κB/Rel transcription factors regulate many genes involved in control of cellular
proliferation, neoplastic transformation, and apoptosis, including the c-myc oncogene …

Polychlorinated biphenyls (PCBs) are ubiquitous global contaminants that have been
intensively investigated for three decades. They are broad-acting toxicants occurring in …