Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission
Executive summary The 2024 update of the Lancet Commission on dementia provides new
hopeful evidence about dementia prevention, intervention, and care. As people live longer …
hopeful evidence about dementia prevention, intervention, and care. As people live longer …
Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting
Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central
nervous system afflicting nearly three million individuals worldwide. Neuroimmune …
nervous system afflicting nearly three million individuals worldwide. Neuroimmune …
The multifaceted role of tissue-resident memory T cells
Regionalized immune surveillance relies on the concerted efforts of diverse memory T cell
populations. Of these, tissue-resident memory T (TRM) cells are strategically positioned in …
populations. Of these, tissue-resident memory T (TRM) cells are strategically positioned in …
Tissue-resident CD8+ T cells drive compartmentalized and chronic autoimmune damage against CNS neurons
D Frieser, A Pignata, L Khajavi, D Shlesinger… - Science translational …, 2022 - science.org
The mechanisms underlying the chronicity of autoimmune diseases of the central nervous
system (CNS) are largely unknown. In particular, it is unclear whether tissue-resident …
system (CNS) are largely unknown. In particular, it is unclear whether tissue-resident …
Assessing the generation of tissue resident memory T cells by vaccines
E Rotrosen, TS Kupper - Nature Reviews Immunology, 2023 - nature.com
Vaccines have been a hugely successful public health intervention, virtually eliminating
many once common diseases of childhood. However, they have had less success in …
many once common diseases of childhood. However, they have had less success in …
High-titer AAV disrupts cerebrovascular integrity and induces lymphocyte infiltration in adult mouse brain
Y Guo, J Chen, W Ji, L Xu, Y **e, S He, C Lai… - … Therapy-Methods & …, 2023 - cell.com
The brain is often described as an" immune-privileged" organ due to the presence of the
blood-brain-barrier (BBB), which limits the entry of immune cells. In general, intracranial …
blood-brain-barrier (BBB), which limits the entry of immune cells. In general, intracranial …
Learning CNS immunopathology from therapeutic interventions
Modulation of immune cell trafficking across the blood-brain barrier has not only introduced
a therapeutic avenue for multiple sclerosis (MS) but also represents an example of reverse …
a therapeutic avenue for multiple sclerosis (MS) but also represents an example of reverse …
Brain resident memory T cells rapidly expand and initiate neuroinflammatory responses following CNS viral infection
The contribution of circulating verses tissue resident memory T cells (TRMs) to clinical
neuropathology is an enduring question due to a lack of mechanistic insights. The prevailing …
neuropathology is an enduring question due to a lack of mechanistic insights. The prevailing …
[HTML][HTML] Life history of a brain autoreactive T cell: from thymus through intestine to blood-brain barrier and brain lesion
N Kawakami, H Wekerle - Neurotherapeutics, 2024 - Elsevier
Brain antigen-specific autoreactive T cells seem to play a key role in inducing inflammation
in the central nervous system (CNS), a characteristic feature of human multiple sclerosis …
in the central nervous system (CNS), a characteristic feature of human multiple sclerosis …
Osteopontin associates with brain TRM-cell transcriptome and compartmentalization in donors with and without multiple sclerosis
CC Hsiao, HJ Engelenburg, A Jongejan, J Zhu… - Iscience, 2023 - cell.com
The human brain is populated by perivascular T cells with a tissue-resident memory T (T
RM)-cell phenotype, which in multiple sclerosis (MS) associate with lesions. We investigated …
RM)-cell phenotype, which in multiple sclerosis (MS) associate with lesions. We investigated …