Role of inflammatory mechanisms in major depressive disorder: from etiology to potential pharmacological targets

BR Kouba, L de Araujo Borba, P Borges de Souza… - Cells, 2024 - mdpi.com
The involvement of central and peripheral inflammation in the pathogenesis and prognosis
of major depressive disorder (MDD) has been demonstrated. The increase of pro …

Neuroprotection by agmatine: Possible involvement of the gut microbiome?

P Saha, S Panda, A Holkar, R Vashishth… - Ageing Research …, 2023 - Elsevier
Agmatine, an endogenous polyamine derived from L-arginine, elicits tremendous
multimodal neuromodulant properties. Alterations in agmatinergic signalling are closely …

Near-infrared photobiomodulation combined with coenzyme Q10 for depression in a mouse model of restraint stress: reduction in oxidative stress, neuroinflammation …

F Salehpour, F Farajdokht, P Cassano… - Brain research …, 2019 - Elsevier
This study was aimed to evaluate the effects of near-infrared (NIR) photobiomodulation
(PBM) combined with coenzyme Q 10 (CoQ 10) on depressive-like behavior, cerebral …

Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice

CH Chiu, CC Chyau, CC Chen, LY Lee… - International journal of …, 2018 - mdpi.com
Antidepressant-like effects of ethanolic extract of Hericium erinaceus (HE) mycelium
enriched in erinacine A on depressive mice challenged by repeated restraint stress (RS) …

Plasma metabolites predict severity of depression and suicidal ideation in psychiatric patients-a multicenter pilot analysis

D Setoyama, TA Kato, R Hashimoto, H Kunugi… - PloS one, 2016 - journals.plos.org
Evaluating the severity of depression (SOD), especially suicidal ideation (SI), is crucial in the
treatment of not only patients with mood disorders but also psychiatric patients in general …

Chronic unpredictable mild stress decreases BDNF and NGF levels and Na+, K+-ATPase activity in the hippocampus and prefrontal cortex of mice: Antidepressant …

CR Jesse, F Donato, R Giacomeli, L Del Fabbro… - Neuroscience, 2015 - Elsevier
Our working hypothesis is that brain neurotrophins and brain Na+, K+-ATPase may be
strongly associated with the occurrence of depression in animals subjected to chronic …

C60 Fullerene Prevents Restraint Stress‐Induced Oxidative Disorders in Rat Tissues: Possible Involvement of the Nrf2/ARE‐Antioxidant Pathway

OO Gonchar, AV Maznychenko… - Oxidative Medicine …, 2018 - Wiley Online Library
The effects of C60FAS (50 and 500 μg/kg) supplementation, in a normal physiological state
and after restraint stress exposure, on prooxidant/antioxidant balance in rat tissues were …

Hesperidin alleviates chronic restraint stress and lipopolysaccharide-induced Hippocampus and Frontal cortex damage in mice: Role of TLR4/NF-κB, p38 MAPK/JNK …

M Kwatra, S Ahmed, B Gawali, SR Panda… - Neurochemistry …, 2020 - Elsevier
Stress and lipopolysaccharide (LPS) animal models are used for screening antidepressants
and anxiolytic drugs. However, the lacunae for their combination (Restraint stress; RS and …

Pathophysiology linking depression and type 2 diabetes: psychotherapy, physical exercise, and fecal microbiome transplantation as damage control

R Subba, R Sandhir, SP Singh… - European Journal of …, 2021 - Wiley Online Library
Diabetes increases the likelihood of develo** depression and vice versa. Research on
this bidirectional association has somewhat managed to delineate the interplay among …

Repeated daily restraint stress induces adaptive behavioural changes in both adult and juvenile mice

AM Sadler, SJ Bailey - Physiology & behavior, 2016 - Elsevier
Chronic stress is known to be a risk factor for the development of depression and anxiety,
disorders which often begin during adolescence. Restraint stress is a commonly used …