Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds

HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …

Novel therapeutic strategies: targeting epithelial–mesenchymal transition in colorectal cancer

N Zhang, AS Ng, S Cai, Q Li, L Yang, D Kerr - The Lancet Oncology, 2021 - thelancet.com
Epithelial–mesenchymal transition (EMT) is a process during which cells lose their epithelial
characteristics, for instance apical–basal cell polarity and cell–cell contact, and gain …

Non-redundant functions of EMT transcription factors

MP Stemmler, RL Eccles, S Brabletz, T Brabletz - Nature cell biology, 2019 - nature.com
Epithelial–mesenchymal transition (EMT) is a crucial embryonic programme that is executed
by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and …

Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells

C Kröger, A Afeyan, J Mraz, EN Eaton… - Proceedings of the …, 2019 - pnas.org
Carcinoma cells residing in an intermediate phenotypic state along the epithelial–
mesenchymal (E–M) spectrum are associated with malignant phenotypes, such as …

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

X Zheng, JL Carstens, J Kim, M Scheible, J Kaye… - Nature, 2015 - nature.com
Diagnosis of pancreatic ductal adenocarcinoma (PDAC) is associated with a dismal
prognosis despite current best therapies; therefore new treatment strategies are urgently …

Regulation of EMT in colorectal cancer: a culprit in metastasis

T Vu, PK Datta - Cancers, 2017 - mdpi.com
Epithelial to mesenchymal transition (EMT) is a process during which cells lose their
epithelial characteristics, for instance cell polarity and cell–cell contact, and gain …

Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

X Ye, WL Tam, T Shibue, Y Kaygusuz, F Reinhardt… - Nature, 2015 - nature.com
Tumour-initiating cells (TICs) are responsible for metastatic dissemination and clinical
relapse in a variety of cancers,. Analogies between TICs and normal tissue stem cells have …

EMT and MET: necessary or permissive for metastasis?

MK Jolly, KE Ware, S Gilja, JA Somarelli… - Molecular …, 2017 - Wiley Online Library
Epithelial‐to‐mesenchymal transition (EMT) and its reverse mesenchymal‐to‐epithelial
transition (MET) have been suggested to play crucial roles in metastatic dissemination of …

An epithelial–mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR …

LA Byers, L Diao, J Wang, P Saintigny… - Clinical cancer …, 2013 - aacrjournals.org
Purpose: Epithelial–mesenchymal transition (EMT) has been associated with metastatic
spread and EGF receptor (EGFR) inhibitor resistance. We developed and validated a robust …

Epithelial–mesenchymal transition and its transcription factors

P Debnath, RS Huirem, P Dutta… - Bioscience …, 2022 - portlandpress.com
Epithelial–mesenchymal transition or EMT is an extremely dynamic process involved in
conversion of epithelial cells into mesenchymal cells, stimulated by an ensemble of …