Neuroinflammation is involved in the onset or progression of various neurodegenerative
diseases. Initiation of neuroinflammation is triggered by endogenous substances (damage …

Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

As a complex multicellular structure of the vascular system at the central nervous system
(CNS), the blood-brain barrier (BBB) separates the CNS from the system circulation and …

The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …

In Alzheimer's disease, amyloid deposits along the brain vasculature lead to a condition
known as cerebral amyloid angiopathy (CAA), which impairs blood–brain barrier (BBB) …

Transient or permanent loss of tissue perfusion due to ischaemic stroke can lead to damage
to the neurovasculature, and disrupt brain homeostasis, causing long-term motor and …

One of the biggest challenges in the development of therapeutics for central nervous system
(CNS) disorders is achieving sufficient blood–brain barrier (BBB) penetration. Research in …

Transepithelial/transendothelial electrical resistance (TEER) is a widely accepted
quantitative technique to measure the integrity of tight junction dynamics in cell culture …

The neurovascular unit, which consists of vascular cells surrounded by astrocytic end-feet
and neurons, controls cerebral blood flow and the permeability of the blood–brain barrier …

Polyphenols are naturally occurring micronutrients that are present in many food sources.
Besides being potent antioxidants, these molecules may also possess anti-inflammatory …