Bacterial Metallostasis: Metal Sensing, Metalloproteome Remodeling, and Metal Trafficking
Transition metals function as structural and catalytic cofactors for a large diversity of proteins
and enzymes that collectively comprise the metalloproteome. Metallostasis considers all …
and enzymes that collectively comprise the metalloproteome. Metallostasis considers all …
Aminoglycoside uptake, stress, and potentiation in Gram-negative bacteria: new therapies with old molecules
Aminoglycosides (AGs) are long-known molecules successfully used against Gram-negative
pathogens. While their use declined with the discovery of new antibiotics, they are now …
pathogens. While their use declined with the discovery of new antibiotics, they are now …
Intermittent antibiotic treatment of bacterial biofilms favors the rapid evolution of resistance
Bacterial antibiotic resistance is a global health concern of increasing importance and
intensive study. Although biofilms are a common source of infections in clinical settings, little …
intensive study. Although biofilms are a common source of infections in clinical settings, little …
[HTML][HTML] An overview of the recent advances in antimicrobial resistance
M Oliveira, W Antunes, S Mota… - …, 2024 - pmc.ncbi.nlm.nih.gov
Antimicrobial resistance (AMR), frequently considered a major global public health threat,
requires a comprehensive understanding of its emergence, mechanisms, advances, and …
requires a comprehensive understanding of its emergence, mechanisms, advances, and …
Bacteria exposed to antiviral drugs develop antibiotic cross-resistance and unique resistance profiles
Antiviral drugs are used globally as treatment and prophylaxis for long-term and acute viral
infections. Even though antivirals also have been shown to have off-target effects on …
infections. Even though antivirals also have been shown to have off-target effects on …
Conserved 5-methyluridine tRNA modification modulates ribosome translocation
JD Jones, MK Franco, RN Giles, DE Eyler… - Proceedings of the …, 2024 - pnas.org
While the centrality of posttranscriptional modifications to RNA biology has long been
acknowledged, the function of the vast majority of modified sites remains to be discovered …
acknowledged, the function of the vast majority of modified sites remains to be discovered …
Biosynthesis and function of 7-deazaguanine derivatives in bacteria and phages
Deazaguanine modifications play multifaceted roles in the molecular biology of DNA and
tRNA, sha** diverse yet essential biological processes, including the nuanced fine-tuning …
tRNA, sha** diverse yet essential biological processes, including the nuanced fine-tuning …
Epitranscriptomic rRNA fingerprinting reveals tissue-of-origin and tumor-specific signatures
Mammalian ribosomal RNA (rRNA) molecules are highly abundant RNAs, decorated with
over 220 rRNA modifications. Previous works have shown that some rRNA modification …
over 220 rRNA modifications. Previous works have shown that some rRNA modification …
What's the matter with MICs: Bacterial nutrition, limiting resources, and antibiotic pharmacodynamics
The MIC of an antibiotic required to prevent replication is used both as a measure of the
susceptibility/resistance of bacteria to that drug and as the single pharmacodynamic …
susceptibility/resistance of bacteria to that drug and as the single pharmacodynamic …
High-throughput method characterizes hundreds of previously unknown antibiotic resistance mutations
A fundamental obstacle to tackling the antimicrobial resistance crisis is identifying mutations
that lead to resistance in a given genomic background and environment. We present a high …
that lead to resistance in a given genomic background and environment. We present a high …