Pathogenesis, symptomatology, and transmission of SARS-CoV-2 through analysis of viral genomics and structure

HM Rando, AL MacLean, AJ Lee, R Lordan, S Ray… - …, 2021 - Am Soc Microbiol
The novel coronavirus SARS-CoV-2, which emerged in late 2019, has since spread around
the world and infected hundreds of millions of people with coronavirus disease 2019 …

Identification and development of therapeutics for COVID-19

HM Rando, N Wellhausen, S Ghosh, AJ Lee… - Msystems, 2021 - Am Soc Microbiol
After emerging in China in late 2019, the novel coronavirus severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) spread worldwide, and as of mid-2021, it remains a …

Guidelines for the prevention and management of children and adolescents with COVID-19

E Liu, RL Smyth, Q Li, A Qaseem, ID Florez… - European Journal of …, 2022 - Springer
Children are the future of the world, but their health and future are facing great uncertainty
because of the coronavirus disease 2019 (COVID-19) pandemic. In order to improve the …

Computational prediction of the molecular mechanism of statin group of drugs against SARS-CoV-2 pathogenesis

D Ghosh, D Ghosh Dastidar, K Roy, A Ghosh… - Scientific Reports, 2022 - nature.com
Recently published clinical data from COVID-19 patients indicated that statin therapy is
associated with a better clinical outcome and a significant reduction in the risk of mortality. In …

Moxidectin and ivermectin inhibit SARS-CoV-2 replication in Vero E6 cells but not in human primary bronchial epithelial cells

N Dinesh Kumar, BM ter Ellen, EM Bouma… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
Antiviral therapies are urgently needed to treat and limit the development of severe COVID-
19 disease. Ivermectin, a broad-spectrum anti-parasitic agent, has been shown to have anti …

The 'myth of Hydroxychloroquine (HCQ) as post-exposure prophylaxis (PEP) for the prevention of COVID-19'is far from reality

DP Dhibar, N Arora, D Chaudhary, A Prakash… - Scientific Reports, 2023 - nature.com
The efficacy of Hydroxychloroquine (HCQ) as post-exposure prophylaxis (PEP) for the
prevention of COVID-19 was contentious. In this randomized control double-blind clinical …

[HTML][HTML] The role of the glucocorticoid receptor and its impact on steroid response in moderate-severe COVID-19 patients

G Aliska, N Nafrialdi, KC Lie, R Setiabudy… - European Journal of …, 2023 - Elsevier
The effect of corticosteroid therapy in COVID-19 patients is mediated by its suppressive
effect on the regulations of inflammatory response. However, its clinical outcome is often …

[HTML][HTML] Moxidectin and ivermectin inhibit SARS-CoV-2 replication in vero E6 cells but not in human primary bronchial epithelial cells

ND Kumar, BM Ter Ellen, EM Bouma… - Antimicrobial Agents …, 2022 - ncbi.nlm.nih.gov
Antiviral therapies are urgently needed to treat and limit the development of severe COVID-
19 disease. Ivermectin, a broad-spectrum anti-parasitic agent, has been shown to have anti …

[HTML][HTML] COVID-19 in children and adolescents: characteristics and specificities in immunocompetent and oncohematological patients

F Mercolini, S Cesaro - Mediterranean Journal of Hematology and …, 2022 - ncbi.nlm.nih.gov
SARS-CoV-2 pandemic affected fewer children and adolescents with lower morbidity and
mortality rates than those reported for adults. This review focused on the clinical course, risk …

Renal and hepatic toxicity analysis of remdesivir formulations: does what is on the inside really count?

S Shah, TW Ackley, JE Topal - Antimicrobial Agents and …, 2021 - Am Soc Microbiol
It has been postulated that the injectable solution formulation of remdesivir could be more
nephrotoxic than the lyophilized powder since it contains twice as much sulfobutylether-β …