As the main protein components of chromatin, histones play central roles in gene regulation
as spools of winding DNA. Histones are subject to various modifications, including …

Histone post-translational modifications (HPTMs), as one of the core mechanisms of
epigenetic regulation, are garnering increasing attention due to their close association with …

Protein post-translation modification plays an important role in regulating DNA repair;
however, the role of arginine methylation in this process is poorly understood. Here we …

Multiple myeloma (MM) is a malignant plasma cell (PC) disorder, characterized by a
complex interactive network of tumour cells and the bone marrow (BM) stromal …

Autoantibodies directed against citrullinated epitopes of proteins are highly diagnostic of
rheumatoid arthritis (RA), and elevated levels of protein citrullination can be found in the …

The post-translational modification of proteins expands the regulatory scope of the proteome
far beyond what is achievable through genome regulation. The field of protein citrullination …

Summary The 53BP1-RIF1-shieldin pathway maintains genome stability by suppressing
nucleolytic degradation of DNA ends at double-strand breaks (DSBs). Although RIF1 …

Cancer stem cells (CSCs), which have a close connection with tumor microenvironment,
play a pivotal role in tumorigenesis, tumor progression, and metastasis. The inflammatory …

Onset of castration-resistance prostate cancer (CRPC) after long-term androgen deprivation
therapy remains a major obstacle in the treatment of prostate cancer. The peptidylarginine …

Citrullination, the post-translational conversion of arginines to citrullines, may contribute to
rheumatoid arthritis development given the generation of anti-citrullinated protein antibodies …