Methods favoring homology-directed repair choice in response to CRISPR/Cas9 induced-double strand breaks
H Yang, S Ren, S Yu, H Pan, T Li, S Ge… - International journal of …, 2020 - mdpi.com
Precise gene editing is—or will soon be—in clinical use for several diseases, and more
applications are under development. The programmable nuclease Cas9, directed by a …
applications are under development. The programmable nuclease Cas9, directed by a …
Cyclin E/CDK2: DNA replication, replication stress and genomic instability
R Fagundes, LK Teixeira - Frontiers in cell and developmental biology, 2021 - frontiersin.org
DNA replication must be precisely controlled in order to maintain genome stability.
Transition through cell cycle phases is regulated by a family of Cyclin-Dependent Kinases …
Transition through cell cycle phases is regulated by a family of Cyclin-Dependent Kinases …
[HTML][HTML] The global phosphorylation landscape of SARS-CoV-2 infection
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …
How cells ensure correct repair of DNA double-strand breaks
J Her, SF Bunting - Journal of Biological Chemistry, 2018 - ASBMB
DNA double-strand breaks (DSBs) arise regularly in cells and when left unrepaired cause
senescence or cell death. Homologous recombination (HR) and nonhomologous end …
senescence or cell death. Homologous recombination (HR) and nonhomologous end …
[HTML][HTML] Cyclin-dependent kinases in DNA damage response
The cyclin-dependent kinase (CDK) family plays a critical role in a variety of signaling
pathways that regulate transcription and cell-cycle progression. Recently, the role of CDKs …
pathways that regulate transcription and cell-cycle progression. Recently, the role of CDKs …
CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth
The mammalian target of rapamycin complex1 (mTORC1) is a central regulator of
metabolism and cell growth by sensing diverse environmental signals, including amino …
metabolism and cell growth by sensing diverse environmental signals, including amino …
DNA repair syndromes and cancer: insights into genetics and phenotype patterns
R Sharma, S Lewis, MW Wlodarski - Frontiers in Pediatrics, 2020 - frontiersin.org
DNA damage response is essential to human physiology. A broad spectrum of pathologies
are displayed by individuals carrying monoallelic or biallelic loss-of-function mutations in …
are displayed by individuals carrying monoallelic or biallelic loss-of-function mutations in …
Loss of ARID1A in tumor cells renders selective vulnerability to combined ionizing radiation and PARP inhibitor therapy
Purpose: Somatic inactivating mutations in ARID1A, a component of the SWI/SNF chromatin
remodeling complex, are detected in various types of human malignancies. Loss of ARID1A …
remodeling complex, are detected in various types of human malignancies. Loss of ARID1A …
Human RecQ helicases in DNA double-strand break repair
RecQ DNA helicases are a conserved protein family found in bacteria, fungus, plants, and
animals. These helicases play important roles in multiple cellular functions, including DNA …
animals. These helicases play important roles in multiple cellular functions, including DNA …
DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response
The DNA damage response (DDR) encompasses the cellular response to DNA double-
stranded breaks (DSBs), and includes recognition of the DSB, recruitment of numerous …
stranded breaks (DSBs), and includes recognition of the DSB, recruitment of numerous …