Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution

AA Pollen, U Kilik, CB Lowe, JG Camp - Nature Reviews Genetics, 2023 - nature.com
Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …

Supervised machine learning for population genetics: a new paradigm

DR Schrider, AD Kern - Trends in Genetics, 2018 - cell.com
As population genomic datasets grow in size, researchers are faced with the daunting task
of making sense of a flood of information. To keep pace with this explosion of data …

The molecular evolution of spermatogenesis across mammals

F Murat, N Mbengue, SB Winge, T Trefzer, E Leushkin… - Nature, 2023 - nature.com
The testis produces gametes through spermatogenesis and evolves rapidly at both the
morphological and molecular level in mammals,,,,–, probably owing to the evolutionary …

Evolution of the human nervous system function, structure, and development

AMM Sousa, KA Meyer, G Santpere, FO Gulden… - Cell, 2017 - cell.com
The nervous system—in particular, the brain and its cognitive abilities—is among humans'
most distinctive and impressive attributes. How the nervous system has changed in the …

Host biology in light of the microbiome: ten principles of holobionts and hologenomes

SR Bordenstein, KR Theis - PLoS biology, 2015 - journals.plos.org
Groundbreaking research on the universality and diversity of microorganisms is now
challenging the life sciences to upgrade fundamental theories that once seemed …

[BOK][B] Are we smart enough to know how smart animals are?

F De Waal - 2016 - books.google.com
A New York Times bestseller:" A passionate and convincing case for the sophistication of
nonhuman minds."—Alison Gopnik, The Atlantic Hailed as a classic, Are We Smart Enough …

Phylosymbiosis: relationships and functional effects of microbial communities across host evolutionary history

AW Brooks, KD Kohl, RM Brucker, EJ van Opstal… - PLoS …, 2016 - journals.plos.org
Phylosymbiosis was recently proposed to describe the eco-evolutionary pattern, whereby
the ecological relatedness of host-associated microbial communities parallels the phylogeny …

Evolution and implications of de novo genes in humans

LA Broeils, J Ruiz-Orera, B Snel, N Hubner… - Nature ecology & …, 2023 - nature.com
Genes and translated open reading frames (ORFs) that emerged de novo from previously
non-coding sequences provide species with opportunities for adaptation. When aberrantly …

Common genetic associations between age-related diseases

HM Dönertaş, DK Fabian, M Fuentealba, L Partridge… - Nature aging, 2021 - nature.com
Age is a common risk factor in many diseases, but the molecular basis for this relationship is
elusive. In this study we identified four disease clusters from 116 diseases in UK Biobank …

Adaptive sequence divergence forged new neurodevelopmental enhancers in humans

RJ Mangan, FC Alsina, F Mosti, JE Sotelo-Fonseca… - Cell, 2022 - cell.com
Searches for the genetic underpinnings of uniquely human traits have focused on human-
specific divergence in conserved genomic regions, which reflects adaptive modifications of …