The paradoxical role of IL-10 in immunity and cancer
Abstract Interleukin-10 (IL-10) produced by a wide-variety of cells is a highly pleiotropic
cytokine. It has been implicated in the pathogenesis and/or development of autoimmune …
cytokine. It has been implicated in the pathogenesis and/or development of autoimmune …
[HTML][HTML] Mechanisms of photoaging and cutaneous photocarcinogenesis, and photoprotective strategies with phytochemicals
Photoaging and photocarcinogenesis are primarily due to solar ultraviolet (UV) radiation,
which alters DNA, cellular antioxidant balance, signal transduction pathways, immunology …
which alters DNA, cellular antioxidant balance, signal transduction pathways, immunology …
Interleukin-10 and the interleukin-10 receptor
KW Moore, R de Waal Malefyt… - Annual review of …, 2001 - annualreviews.org
Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of
T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on …
T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on …
Interleukin-10 therapy—review of a new approach
K Asadullah, W Sterry, HD Volk - Pharmacological reviews, 2003 - Elsevier
Abstract Interleukin (IL)-10 is an important immunoregulatory cytokine produced by many
cell populations. Its main biological function seems to be the limitation and termination of …
cell populations. Its main biological function seems to be the limitation and termination of …
Pathologic patterns of interleukin 10 expression–a review
Sažetak Interleukin 10 (IL-10) is important pleiotropic immunoregulatory cytokine which
gene is located on chromosome 1 at 1q31-32. There are many genetic variants of IL-10 …
gene is located on chromosome 1 at 1q31-32. There are many genetic variants of IL-10 …
Strategies for use of IL‐10 or its antagonists in human disease
Interleukin‐10 (IL‐10) is a cytokine with broad anti‐inflammatory properties by its
suppression of both macrophage and dendritic cell function, including antigen‐presenting …
suppression of both macrophage and dendritic cell function, including antigen‐presenting …
Immune resistance orchestrated by the tumor microenvironment
It is now little disputed that most if not all cancer cells express antigens that can be
recognized by specific CD8+ T lymphocytes. However, a central question in the field of anti …
recognized by specific CD8+ T lymphocytes. However, a central question in the field of anti …
Interleukin-10–Treated Human Dendritic Cells Induce a Melanoma-Antigen–Specific Anergy in CD8+ T Cells Resulting in a Failure to Lyse Tumor Cells
K Steinbrink, H Jonuleit, G Muller… - Blood, The Journal …, 1999 - ashpublications.org
Dendritic cells (DC) are critically involved in the initiation of primary immune processes,
including tumor rejection. In our study, we investigated the effect of interleukin-10 (IL-10) …
including tumor rejection. In our study, we investigated the effect of interleukin-10 (IL-10) …
Dendritic cell dysfunction in cancer: a mechanism for immunosuppression
A Pinzon‐Charry, T Maxwell… - Immunology and cell …, 2005 - Wiley Online Library
Several reports have demonstrated that tumours are not intrinsically resistant to the immune
response. However, neoplasias commonly fail to initiate and maintain adequate immunity. A …
response. However, neoplasias commonly fail to initiate and maintain adequate immunity. A …
Role of interleukin-10 in breast cancer
Cytokines are low molecular weight regulatory proteins or glycoprotein that modulates the
intensity and duration of immune response by stimulating or inhibiting the activation …
intensity and duration of immune response by stimulating or inhibiting the activation …