The paradoxical role of IL-10 in immunity and cancer

MH Mannino, Z Zhu, H **ao, Q Bai, MR Wakefield… - Cancer letters, 2015 - Elsevier
Abstract Interleukin-10 (IL-10) produced by a wide-variety of cells is a highly pleiotropic
cytokine. It has been implicated in the pathogenesis and/or development of autoimmune …

[HTML][HTML] Mechanisms of photoaging and cutaneous photocarcinogenesis, and photoprotective strategies with phytochemicals

R Bosch, N Philips, JA Suárez-Pérez, A Juarranz… - Antioxidants, 2015 - mdpi.com
Photoaging and photocarcinogenesis are primarily due to solar ultraviolet (UV) radiation,
which alters DNA, cellular antioxidant balance, signal transduction pathways, immunology …

Interleukin-10 and the interleukin-10 receptor

KW Moore, R de Waal Malefyt… - Annual review of …, 2001 - annualreviews.org
Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of
T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on …

Interleukin-10 therapy—review of a new approach

K Asadullah, W Sterry, HD Volk - Pharmacological reviews, 2003 - Elsevier
Abstract Interleukin (IL)-10 is an important immunoregulatory cytokine produced by many
cell populations. Its main biological function seems to be the limitation and termination of …

Pathologic patterns of interleukin 10 expression–a review

J Trifunović, L Miller, Ž Debeljak, V Horvat - Biochemia medica, 2015 - hrcak.srce.hr
Sažetak Interleukin 10 (IL-10) is important pleiotropic immunoregulatory cytokine which
gene is located on chromosome 1 at 1q31-32. There are many genetic variants of IL-10 …

Strategies for use of IL‐10 or its antagonists in human disease

A O'Garra, FJ Barrat, AG Castro, A Vicari… - Immunological …, 2008 - Wiley Online Library
Interleukin‐10 (IL‐10) is a cytokine with broad anti‐inflammatory properties by its
suppression of both macrophage and dendritic cell function, including antigen‐presenting …

Immune resistance orchestrated by the tumor microenvironment

TF Gajewski, Y Meng, C Blank, I Brown… - Immunological …, 2006 - Wiley Online Library
It is now little disputed that most if not all cancer cells express antigens that can be
recognized by specific CD8+ T lymphocytes. However, a central question in the field of anti …

Interleukin-10–Treated Human Dendritic Cells Induce a Melanoma-Antigen–Specific Anergy in CD8+ T Cells Resulting in a Failure to Lyse Tumor Cells

K Steinbrink, H Jonuleit, G Muller… - Blood, The Journal …, 1999 - ashpublications.org
Dendritic cells (DC) are critically involved in the initiation of primary immune processes,
including tumor rejection. In our study, we investigated the effect of interleukin-10 (IL-10) …

Dendritic cell dysfunction in cancer: a mechanism for immunosuppression

A Pinzon‐Charry, T Maxwell… - Immunology and cell …, 2005 - Wiley Online Library
Several reports have demonstrated that tumours are not intrinsically resistant to the immune
response. However, neoplasias commonly fail to initiate and maintain adequate immunity. A …

Role of interleukin-10 in breast cancer

Hamidullah, B Changkija, R Konwar - Breast cancer research and …, 2012 - Springer
Cytokines are low molecular weight regulatory proteins or glycoprotein that modulates the
intensity and duration of immune response by stimulating or inhibiting the activation …