Executive summary “Depression is a disorder of mood, so mysteriously painful and elusive
in the way it becomes known to the self—to the mediating intellect—as to verge close to …

The aim of this article is to discuss the validity of relapse prevention trials and the issue of
withdrawal confounding in these trials. Recommendations for long-term antidepressant …

The COVID-19 pandemic and the measures required to address it are cutting a swathe
through people's lives and the global economy. People with addictive disorders are …

In the US, an opioid overdose crisis has emerged, attributable to over-prescription of opioid
analgesics, driven by aggressive marketing by pharmaceutical companies, followed by …

Background Gabapentinoid drugs (gabapentin and pregabalin) are effective in neuropathic
pain, which has a prevalence of∼ 7%. Concerns about increased prescribing have …

Objective To investigate the efficacy and safety of antidepressants for back and osteoarthritis
pain compared with placebo. Design Systematic review and meta-analysis. Data sources …

Background: Protracted withdrawal syndrome (PWS) after stop** antidepressants
(frequently also referred to as post-acute withdrawal syndrome or PAWS) has been …

Neuropathic pain is generally defined as a non-physiological pain experience caused by
damage to the nervous system. It can occur spontaneously, as a reaction to a given stimulus …

The increase in opioid prescriptions in the United States has been accompanied by an
increase in misuse as well as overdose and toxicity related morbidity and mortality …

Background We sought to understand more about the nature and possible consequences of
antidepressant withdrawal. Methods We surveyed members of 20 peer-led, online groups …