The rapidly expanding field of big data analytics has started to play a pivotal role in the
evolution of healthcare practices and research. It has provided tools to accumulate, manage …

Reconstructed microbial metabolic networks facilitate a mechanistic description of the
genotype–phenotype relationship through the deployment of constraint-based …

Remodeling of the tricarboxylic acid (TCA) cycle is a metabolic adaptation accompanying
inflammatory macrophage activation. During this process, endogenous metabolites can …

Metabologenomics integrates metabolomics with other omics data types to comprehensively
study the genetic and environmental factors that influence metabolism. These multi-omics …

Constraint-based models of metabolism are a widely used framework for predicting flux
distributions in genome-scale biochemical networks. The number of published methods for …

Hepatocellular carcinoma (HCC) is one of the most frequent forms of liver cancer, and
effective treatment methods are limited due to tumor heterogeneity. There is a great need for …

PaintOmics is a web server for the integrative analysis and visualisation of multi-omics
datasets using biological pathway maps. PaintOmics 4 has several notable updates that …

Systemic approaches to the study of a biological cell or tissue rely increasingly on the use of
context-specific metabolic network models. The reconstruction of such a model from high …

With the advent of high-throughput technologies, the field of systems biology has amassed
an abundance of “omics” data, quantifying thousands of cellular components across a …

Chemical synthesis is a well established route for producing many chemicals on a large
scale, but some drawbacks still exist in this process, such as unstable intermediates …