Neutrophils are major effectors and regulators of the immune system. They play critical roles
not only in the eradication of pathogens but also in cancer initiation and progression …

Protein tyrosine phosphatase 1B (PTP1B), a non-transmembrane phosphatase, has a major
role in a variety of signalling pathways, including direct negative regulation of classic insulin …

Antibodies can initiate lung injury in a variety of disease states such as autoimmunity, in
reactions to transfusions, or after organ transplantation, but the key factors determining in …

Transfusion-related acute lung injury (TRALI) is a severe adverse event and a leading cause
of transfusion-associated death. Its poor associated prognosis is due, in large part, to the …

BACKGROUND: Endothelial activation promotes the release of procoagulant extracellular
vesicles and inflammatory mediators from specialized storage granules. Endothelial …

Sepsis is defined as a life-threatening dysfunction due to a dysregulated host response to
infection. It is a common and complex syndrome and is the leading cause of death in …

Neutrophils are rapidly recruited to sites of infection and are critical for pathogen clearance.
Therapeutic use of primary neutrophils has been limited, as they have a short lifespan and …

Protein tyrosine phosphatases (PTPs) are critical regulators of signal transduction but have
yet to be exploited fully for drug development. Receptor protein tyrosine phosphatase δ …

A growing of evidence has showed that patients with osteoarthritis (OA) had a higher
coronavirus 2019 (COVID-19) infection rate and a poorer prognosis after infected it …

CXCR4 hi neutrophils, which are a subset of neutrophils with high CXCR4 expression, are
important contributors to sepsis-induced acute lung injury (ALI). PFKFB3, a key glycolysis …