Recent developments in bioprocessing of recombinant proteins: expression hosts and process development
NK Tripathi, A Shrivastava - Frontiers in Bioengineering and …, 2019 - frontiersin.org
Infectious diseases, along with cancers, are among the main causes of death among
humans worldwide. The production of therapeutic proteins for treating diseases at large …
humans worldwide. The production of therapeutic proteins for treating diseases at large …
Antibody‐incorporated nanomedicines for cancer therapy
Antibody‐based cancer therapy, one of the most significant therapeutic strategies, has
achieved considerable success and progress over the past decades. Nevertheless …
achieved considerable success and progress over the past decades. Nevertheless …
Single-domain antibodies as versatile affinity reagents for analytical and diagnostic applications
G Gonzalez-Sapienza, MA Rossotti… - Frontiers in …, 2017 - frontiersin.org
With just three CDRs in their variable domains, the antigen-binding site of camelid heavy-
chain-only antibodies (HcAbs) has a more limited structural diversity than that of …
chain-only antibodies (HcAbs) has a more limited structural diversity than that of …
Solubility, stability, and avidity of recombinant antibody fragments expressed in microorganisms
Solubility of recombinant proteins (ie, the extent of soluble versus insoluble expression in
heterogeneous hosts) is the first checkpoint criterion for determining recombinant protein …
heterogeneous hosts) is the first checkpoint criterion for determining recombinant protein …
Microbial protein cell factories fight back?
LA Rettenbacher, K Arauzo-Aguilera, L Buscajoni… - Trends in …, 2022 - cell.com
The biopharmaceutical market is growing faster than ever, with two production systems
competing for market dominance: mammalian cells and microorganisms. In recent years …
competing for market dominance: mammalian cells and microorganisms. In recent years …
Translatable high drug loading drug delivery systems based on biocompatible polymer nanocarriers
Most nanocarriers possess low drug loading, resulting in frequently repeated administration
and thereby high cost and increased side effects. Furthermore, the characteristics of …
and thereby high cost and increased side effects. Furthermore, the characteristics of …
Single‐chain fragment variable produced by phage display technology: Construction, selection, mutation, expression, and recent applications in food safety
L Li, S Wu, Y Si, H Li, X Yin… - Comprehensive Reviews in …, 2022 - Wiley Online Library
Immunoassays are reliable, efficient, and accurate methods for the analysis of small‐
molecule harmful substances (such as pesticides, veterinary drugs, and biological toxins) …
molecule harmful substances (such as pesticides, veterinary drugs, and biological toxins) …
Antibody fragments as potential biopharmaceuticals for cancer therapy: success and limitations
RV Kholodenko, DV Kalinovsky… - Current Medicinal …, 2019 - ingentaconnect.com
Monoclonal antibodies (mAbs) are an important class of therapeutic agents approved for the
therapy of many types of malignancies. However, in certain cases applications of …
therapy of many types of malignancies. However, in certain cases applications of …
Glycosylation control technologies for recombinant therapeutic proteins
SK Gupta, P Shukla - Applied microbiology and biotechnology, 2018 - Springer
Protein glycosylation is a very important quality attribute of any biopharmaceutical product
as it affects the efficacy, serum half-life, and antigenicity of a molecule. The present …
as it affects the efficacy, serum half-life, and antigenicity of a molecule. The present …
An Alkaline Protease from Bacillus pumilus MP 27: Functional Analysis of Its Binding Model toward Its Applications As Detergent Additive
A proteolytic strain of Bacillus pumilus MP 27 was isolated from water samples of Southern
ocean produced alkaline protease. Since protease production need expensive ingredients …
ocean produced alkaline protease. Since protease production need expensive ingredients …