The core pathology of coronavirus disease 2019 (COVID-19) is infection of airway cells by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive …

Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

The role of mitochondrial function in health and disease has become increasingly
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …

Aging of the vasculature plays a central role in morbidity and mortality of older people. To
develop novel treatments for amelioration of unsuccessful vascular aging and prevention of …

Senescence compromises the essential role that the endothelium plays in maintaining
vascular homeostasis, so promoting endothelial dysfunction and the development of age …

Mitochondrial DNA copy number (mtDNA-CN) is a biomarker of mitochondrial function and
levels of mtDNA-CN have been reproducibly associated with overall mortality and a number …

Cardiovascular disease (CVD) is a leading cause of mortality worldwide. Proper
mitochondrial function is necessary in tissues and organs that are of high energy demand …

Byproducts of normal mitochondrial metabolism and homeostasis include the buildup of
potentially damaging levels of reactive oxygen species (ROS), Ca2+, etc., which must be …

Ageing is the main risk factor for the development of cardiovascular diseases. A central
mechanism by which ageing promotes vascular pathologies is compromising endothelial …

Approximately half of all patients with heart failure have preserved ejection fraction (HFpEF)
and, as life expectancies continue to increase in western societies, the prevalence of HFpEF …