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Review on Contemporary Synthetic Recipes to Access Versatile Coumarin Heterocycles
Coumarin and its derivatives are extensively used as scaffolds in the synthesis of novel
heterocyclic motifs. In the literature, several approaches especially involving metal and …
heterocyclic motifs. In the literature, several approaches especially involving metal and …
Exploration of Indolo [3, 2c] isoquinoline derived triazoles as potential antimicrobial and DNA cleavage agents: synthesis, DFT calculations, and molecular modeling …
Indole and its derivatives are well-known assorted motif in drug design and development.
We here in reporting synthesis of new 9-chloro-1-(4-substituted phenyl)-12H-indolo [2, 3 …
We here in reporting synthesis of new 9-chloro-1-(4-substituted phenyl)-12H-indolo [2, 3 …
Investigating the molecular interactions of 11-substituted-1-(4-chlorophenyl)-8H-indolo [3, 2-c][1, 2, 4] triazolo [3, 4-a] isoquinolines for Antimicrobial Potential …
Indole molecules are one of the important scaffolds in the discovery and development of
new drugs. We herein described a synthesis of new 11-substituted-1-(4-chlorophenyl)-8H …
new drugs. We herein described a synthesis of new 11-substituted-1-(4-chlorophenyl)-8H …
Anticancer and anti-inflammatory activities of garcinol and its analogs
Bioactive molecules have been significantly known for therapeutic potential. One such
molecule, garcinol, is a naturally occurring benzophenone derived from medicinally …
molecule, garcinol, is a naturally occurring benzophenone derived from medicinally …
[HTML][HTML] In-silico exploration and structure-based design of praziquantel derivatives as potential inhibitors of schistosoma mansoni Glutathione S-transferase (SmGST)
Schistosomiasis is a chronic parasitic disease with significant public health challenges due
to the limited number of treatment options and increasing levels of drug resistance against …
to the limited number of treatment options and increasing levels of drug resistance against …
[HTML][HTML] In silico approach to design new cyclooxygenase-2 (COX-2) inhibitors based on MM/QM and ADMET analysis
In spite of the availability of inhibitors targeting the Cyclooxygenase-2 (COX-2) enzyme,
there persists a need for current medications, not solely within the realm of non-steroidal anti …
there persists a need for current medications, not solely within the realm of non-steroidal anti …
[HTML][HTML] Novel 1, 2, 3-triazolic compounds derived from cytosine: Synthesis, spectroscopic characterization, in vitro antimicrobial activity and molecular docking studies
M Lahyaoui, R Sghyar, K Benamar, M Filali… - Results in …, 2024 - Elsevier
The development of novel antimicrobial drugs is crucial due to the increasing problem of
antibiotic resistance. A new series of 1, 4-disubstituted-1, 2, 3-triazole derivatives containing …
antibiotic resistance. A new series of 1, 4-disubstituted-1, 2, 3-triazole derivatives containing …
Novel uracil derivatives as anti-cancer agents: design, synthesis, biological evaluation and computational studies
Ten novel uracil-azole hybrides (4a-4j) were designed and synthesized as anti-cancer
agents. IR, 1 HNMR, 13 CNMR, and Mass spectroscopy were applied to confirm the …
agents. IR, 1 HNMR, 13 CNMR, and Mass spectroscopy were applied to confirm the …
Discovery of Novel Isatin Encompassing Oxadiazoles as Potential Inhibitors against New Delhi Metallo-β-lactamase-1: Synthesis, Spectral Analysis, Antimicrobial, and …
Objective: Efficient synthesis of isatin Schiff's bases (IIIa–IIId) and isatin-derived 1, 3, 4-
oxadizoles (IVa–IVd) and evaluation of their in vitro antibacterial, antifungal, and anti-TB …
oxadizoles (IVa–IVd) and evaluation of their in vitro antibacterial, antifungal, and anti-TB …
Synthesis, Structural, DFT studies, Biological Effectiveness, and Molecular Docking Aspects of Multitarget Novel N-(4-Phenylthiazol-2-yl) hydrazine carboxamide …
We herein report, a series of N-(4-phenylthiazol-2-yl) hydrazinecarboxamide based
multitarget compounds 3 (ai) were designed and synthesized. Ten compounds 2, and 3 (ai) …
multitarget compounds 3 (ai) were designed and synthesized. Ten compounds 2, and 3 (ai) …