What is the role of peptide fragments of collagen I and IV in health and disease?

A Kisling, RM Lust, LC Katwa - Life sciences, 2019 - Elsevier
Collagen is the most abundant protein in mammalian systems; it can be found in organs
such as bones, the liver, kidney, heart, teeth, and skin. Collagen provides the necessary …

Pathogenesis of glaucoma: Extracellular matrix dysfunction in the trabecular meshwork‐A review

KE Keller, DM Peters - Clinical & experimental ophthalmology, 2022 - Wiley Online Library
The trabecular meshwork regulates aqueous humour outflow from the anterior chamber of
the eye. It does this by establishing a tunable outflow resistance, defined by the interplay …

Three-dimensional collagen matrix induces a mechanosensitive invasive epithelial phenotype

SP Carey, KE Martin, CA Reinhart-King - Scientific reports, 2017 - nature.com
A critical step in breast cancer progression is local tissue invasion, during which cells pass
from the epithelial compartment to the stromal compartment. We recently showed that …

[HTML][HTML] Multilevel regulation of matrix metalloproteinases in tissue homeostasis indicates their molecular specificity in vivo

J Gaffney, I Solomonov, E Zehorai, I Sagi - Matrix Biology, 2015 - Elsevier
The matrix metalloproteinases (MMPs) play a crucial role in irreversible remodeling of the
extracellular matrix (ECM) in normal homeostasis and pathological states. Accumulating …

Proteases decode the extracellular matrix cryptome

S Ricard-Blum, SD Vallet - Biochimie, 2016 - Elsevier
The extracellular matrix is comprised of 1100 core-matrisome and matrisome-associated
proteins and of glycosaminoglycans. This structural scaffold contributes to the organization …

Homeostatic regulation of pro-angiogenic and anti-angiogenic proteins via hedgehog, notch grid, and ephrin signaling in tibial dyschondroplasia

S Nawaz, MFA Kulyar, Q Mo, W Yao, M Iqbal, J Li - Animals, 2023 - mdpi.com
Simple Summary Tibial dyschondroplasia (TD) is an avian metabolic disease characterized
by rapid apoptosis and reduced angiogenesis with compromised chondrocyte activity at the …

Increased precision of orthotopic and metastatic breast cancer surgery guided by matrix metalloproteinase-activatable near-infrared fluorescence probes

C Chi, Q Zhang, Y Mao, D Kou, J Qiu, J Ye, J Wang… - Scientific Reports, 2015 - nature.com
Advanced medical imaging technology has allowed the use of fluorescence molecular
imaging-guided breast cancer surgery (FMI-guided BCS) to specifically label tumour cells …

NC1‐peptide regulates spermatogenesis through changes in cytoskeletal organization mediated by EB1

S Liu, H Li, S Wu, L Li, R Ge, CY Cheng - The FASEB Journal, 2020 - Wiley Online Library
During the epithelial cycle of spermatogenesis, different sets of cellular events take place
across the seminiferous epithelium in the testis. For instance, remodeling of the blood‐testis …

Expression of CXCR4 and MMP-2 is associated with poor prognosis in patients with osteosarcoma

C Gong, K Sun, H **ong, T Sneh, J Zhang, X Zhou… - 2020 - digitum.um.es
Backgroud. Osteosarcoma is a primary malignant tumor with a high tendency to form
metastasis and poor prognosis. Consequently, finding effective early indicators of …

MMP-2 isoforms in aortic tissue and serum of patients with ascending aortic aneurysms and aortic root aneurysms

A Tscheuschler, P Meffert, F Beyersdorf, C Heilmann… - PLoS …, 2016 - journals.plos.org
Objective The need for biological markers of aortic wall stress and risk of rupture or
dissection of ascending aortic aneurysms is obvious. To date, wall stress cannot be related …