[HTML][HTML] miRNA: a promising therapeutic target in cancer

A Menon, N Abd-Aziz, K Khalid, CL Poh… - International journal of …, 2022 - mdpi.com
microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by
complementarity pairing. Since discovery, they have been reported to be involved in a …

MicroRNA-155: a master regulator of inflammation

G Mahesh, R Biswas - Journal of Interferon & Cytokine Research, 2019 - liebertpub.com
MicroRNAs (miRNAs) are naturally occurring, highly conserved families of transcripts (∼ 22
nucleotides in length) that are processed from larger hairpin precursors. miRNAs primarily …

MicroRNAs as regulatory elements in immune system logic

A Mehta, D Baltimore - Nature Reviews Immunology, 2016 - nature.com
MicroRNAs (miRNAs) are crucial post-transcriptional regulators of haematopoietic cell fate
decisions. They act by negatively regulating the expression of key immune development …

Molecular mechanisms that influence the macrophage M1–M2 polarization balance

N Wang, H Liang, K Zen - Frontiers in immunology, 2014 - frontiersin.org
As an essential component of innate immunity, macrophages have multiple functions in both
inhibiting or promoting cell proliferation and tissue repair. Diversity and plasticity are …

Exosome-delivered microRNAs modulate the inflammatory response to endotoxin

M Alexander, R Hu, MC Runtsch, DA Kagele… - Nature …, 2015 - nature.com
MicroRNAs regulate gene expression posttranscriptionally and function within the cells in
which they are transcribed. However, recent evidence suggests that microRNAs can be …

Cobomarsen, an oligonucleotide inhibitor of miR‐155, co‐ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T …

AG Seto, X Beatty, JM Lynch… - British journal of …, 2018 - Wiley Online Library
Summary miR‐155, a microRNA associated with poor prognosis in lymphoma and
leukaemia, has been implicated in the progression of mycosis fungoides (MF), the most …

A narrative review of tumor-associated macrophages in lung cancer: regulation of macrophage polarization and therapeutic implications

SS Sedighzadeh, AP Khoshbin, S Razi… - Translational lung …, 2021 - pmc.ncbi.nlm.nih.gov
Lung cancer is the deadliest malignancy worldwide. An inflammatory microenvironment is a
key factor contributing to lung tumor progression. Tumor-Associated Macrophages (TAMs) …

MicroRNAs in cancer

G Di Leva, M Garofalo, CM Croce - Annual Review of Pathology …, 2014 - annualreviews.org
MicroRNAs (miRNAs) are small noncoding RNAs that typically inhibit the translation and
stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such …

Risk factors and biomarkers of age-related macular degeneration

NG Lambert, H ElShelmani, MK Singh… - Progress in retinal and …, 2016 - Elsevier
A biomarker can be a substance or structure measured in body parts, fluids or products that
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …

Molecular biomarkers in acute myeloid leukemia

J Prada-Arismendy, JC Arroyave, S Röthlisberger - Blood reviews, 2017 - Elsevier
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. The
pathophysiology of this disease is just beginning to be understood at the cellular and …