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[HTML][HTML] miRNA: a promising therapeutic target in cancer
microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by
complementarity pairing. Since discovery, they have been reported to be involved in a …
complementarity pairing. Since discovery, they have been reported to be involved in a …
MicroRNA-155: a master regulator of inflammation
MicroRNAs (miRNAs) are naturally occurring, highly conserved families of transcripts (∼ 22
nucleotides in length) that are processed from larger hairpin precursors. miRNAs primarily …
nucleotides in length) that are processed from larger hairpin precursors. miRNAs primarily …
MicroRNAs as regulatory elements in immune system logic
A Mehta, D Baltimore - Nature Reviews Immunology, 2016 - nature.com
MicroRNAs (miRNAs) are crucial post-transcriptional regulators of haematopoietic cell fate
decisions. They act by negatively regulating the expression of key immune development …
decisions. They act by negatively regulating the expression of key immune development …
Molecular mechanisms that influence the macrophage M1–M2 polarization balance
N Wang, H Liang, K Zen - Frontiers in immunology, 2014 - frontiersin.org
As an essential component of innate immunity, macrophages have multiple functions in both
inhibiting or promoting cell proliferation and tissue repair. Diversity and plasticity are …
inhibiting or promoting cell proliferation and tissue repair. Diversity and plasticity are …
Exosome-delivered microRNAs modulate the inflammatory response to endotoxin
MicroRNAs regulate gene expression posttranscriptionally and function within the cells in
which they are transcribed. However, recent evidence suggests that microRNAs can be …
which they are transcribed. However, recent evidence suggests that microRNAs can be …
Cobomarsen, an oligonucleotide inhibitor of miR‐155, co‐ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T …
AG Seto, X Beatty, JM Lynch… - British journal of …, 2018 - Wiley Online Library
Summary miR‐155, a microRNA associated with poor prognosis in lymphoma and
leukaemia, has been implicated in the progression of mycosis fungoides (MF), the most …
leukaemia, has been implicated in the progression of mycosis fungoides (MF), the most …
A narrative review of tumor-associated macrophages in lung cancer: regulation of macrophage polarization and therapeutic implications
SS Sedighzadeh, AP Khoshbin, S Razi… - Translational lung …, 2021 - pmc.ncbi.nlm.nih.gov
Lung cancer is the deadliest malignancy worldwide. An inflammatory microenvironment is a
key factor contributing to lung tumor progression. Tumor-Associated Macrophages (TAMs) …
key factor contributing to lung tumor progression. Tumor-Associated Macrophages (TAMs) …
MicroRNAs in cancer
G Di Leva, M Garofalo, CM Croce - Annual Review of Pathology …, 2014 - annualreviews.org
MicroRNAs (miRNAs) are small noncoding RNAs that typically inhibit the translation and
stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such …
stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such …
Risk factors and biomarkers of age-related macular degeneration
NG Lambert, H ElShelmani, MK Singh… - Progress in retinal and …, 2016 - Elsevier
A biomarker can be a substance or structure measured in body parts, fluids or products that
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …
Molecular biomarkers in acute myeloid leukemia
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. The
pathophysiology of this disease is just beginning to be understood at the cellular and …
pathophysiology of this disease is just beginning to be understood at the cellular and …